Peter Torzilli, PhD

Selected Publications

Lucchinetti, E., Adams, C.S., Horton Jr., W.E. and Torzilli, P.A.(2002) Cartilage Viability After Repetitive Loading. A Preliminary Report. Osteoarthritis & Cartilage, 10:71-81.

Chen, C-T, Bhargava, M.., Lin, P. and Torzilli, P.A.. (2003) Time, Stress, and Location Dependent Chondrocyte Death and Collagen Damage in Cyclically Loaded Articular Cartilage. Journal of Orthopaedic Research, 21:888B898.

Milentijevic, D., Helfet, D.L .and Torzilli, P.A. (2003) Influence of Stress Magnitude on Water Loss and Chondrocyte Viability in Impacted Articular Cartilage. Journal of Biomechanical Engineering, 125:594-601.

Lucchinetti, E., Bhargava, M.M. and Torzilli, P.A. (2004) The Effect of Mechanical Load on the Expression of the Integrin Subunits a5 and ß1 in Chondrocytes from Mature and Immature Cartilage Explants. Cell and Tissue Research, 315:385-391.

Milentijevic, D. and Torzilli, P.A. (2005) Influence of Stress Rate on Water Loss, Matrix Deformation and Chondrocyte Viability in Impacted Articular Cartilage. Journal of Biomechanics, 38:493-502.

Levin, A.S., Chen, C-T. and Torzilli, P.A. (2005) Effect of Tissue Maturity on Cell Viability in Mechanically Loaded Articular Cartilage. Osteoarthritis and Cartilage, 13:488-496.

Torzilli, P.A., Deng, X-H. and Ramcharan, M. (2006) Effect of Compressive Strain on Cell Viability in Statically Loaded Articular Cartilage. Biomechanics and Modeling in Mechanobiology, 5:123-132.

Maher, S. A., Doty, S. B., Torzilli, P. A., Thornton, S., Lowman, A. M., Thomas, J. D., Warren, R., Wright, T. M., and Myers, E. (2007) Nondegradable hydrogels for the treatment of focal cartilage defects. J Biomedical Materials Research A, 83:145-155.

Wyatt, K. E-K., Bourne, J.W. and Torzilli, P.A. (2009) Deformation-Dependent Enzyme Mechanokinetic Cleavage of Type I Collagen. Journal of Biomechanical Engineering, 131: 051004-1-9.

For more publications, please see the PubMed listing.

Research Description

Mechanobiology, Molecular Engineering, Enzyme Mechanokinetics and Tissue Engineering of Musculoskeletal Soft Tissues

Major areas of research are in the study of cell and tissue biology, function and biomechanics of articular cartilage in health and disease; the enzyme mechanokinetics of collagen catalysis; the engineering of biocompatible materials for repair and replacement of damaged tissues; and the design of novel approaches at the molecular level to enhance soft tissue repair and function. Basic and applied research is performed at the molecular, cellular, tissue and whole joint levels. Of particular interest are questions concerning how cells respond to injury or disease (metabolism); how cellular response effects the matrix components (composition and arrangement); how these changes influence the tissue's physical performance (biomechanical properties); how we can repair and restructure the tissue's damaged microstructure (termed tissue engineering) through normal biological pathways (cellular engineering) or synthetic pathways (molecular engineering); how natural and synthetic materials can be combined to produce biocompatible tissue constructs (biomaterials); how genetically engineered cells (gene therapy) can be used to repair damaged tissues; and how cells and biologically compatible biomaterials can be combined to produce a viable replacement for damaged tissues.

Clinical Trials

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Contact Information

Office Locations

Caspary Research Building
541 East 71st Street
New York, NY 10021

Tel: (212) 606-1087
 

Mailing Address

Hospital for Special Surgery
535 East 70th Street
New York, New York 10021