Chisa Hidaka, MD
Chondrocyte-based cartilage repair and regeneration
Our long term goal is to discover better ways to repair and regenerate joint cartilage through an improved understanding of the biology of chondrocytes (cartilage cells). Our focus is on genes whose activities control the growth and development of joint cartilage.
Having received fellowship training in gene therapy, our previous work was centered on the use of gene transfer to attempt to enhance cartilage repair. The gene that we used in that work was the bone morphogenetic protein (BMP) gene. Transfer of the BMP gene was found not only to accelerate early stages of cartilage repair, but to improve bone formation. For bone formation, combined treatment with two different BMP genes was particularly effective.
Current projects are focused on the study of other genes that may be important for cartilage growth and joint development. When cartilage is injured, it does not mount a classic healing response in the way other tissues such as skin or bone are able to do. By studying how cartilage normally develops, we hope to discover new strategies to support new cartilage growth after injury or degeneration.
Appointments
Assistant Scientist, Hospital for Special Surgery
Primary Investigator, Institute for Sports Medicine Research, NY
Selected Publications
Zhu W, Rawlins BA, Boachie-Adjei O, Myers ER, Arimizu J, Choi E, Lieberman JR, Crystal RG, Hidaka C. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res. 2004 Dec;19(12):2021-32. Epub 2004 Aug 30.
Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG. Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine. 2003 Sep 15;28(18):2049-57.
Hidaka C, Goodrich LR, Chen CT, Warren RF, Crystal RG, Nixon AJ. Related Articles, Links Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7. J Orthop Res. 2003 Jul;21(4):573-83.
Hidaka C, Quitoriano M, Warren RF, Crystal RG. Enhanced matrix synthesis and in vitro formation of cartilage-like tissue by genetically modified chondrocytes expressing BMP-7. J Orthop Res. 2001 Sep;19(5):751-8.
Hidaka C, Milano E, Leopold PL, Bergelson JM, Hackett NR, Finberg RW, Wickham TJ, Kovesdi I, Roelvink P, Crystal RG. CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts. J Clin Invest. 1999 Feb;103(4):579-87.
For more publications, please see the
PubMed listing.
