Mary Goldring, PhD

Appointments

Senior Scientist, HSS Research Division

Director, Laboratory for Cartilage Biology, Tissue Engineering Repair & Regeneration Program

Professor of Cell and Developmental Biology, Weill Cornell Medical College

Selected Publications

Ijiri K, Zerbini LF, Peng H, Otu HH, Tsuchimochi K, Otero M, Dragomir C, Walsh N, Bierbaum BE, Mattingly D, van Flandern G, Komiya S, Aigner T, Libermann TA, Goldring MB. Differential expression of GADD45bin normal and osteoarthritic cartilage: Potential role in homeostasis of articular chondrocytes. Arthritis Rheum 2008; 58:2075-2087.

Peng H, Tan L, Osaki M, Zhan Y, Ijiri K, Tsuchimochi K, Otero M, Wang H, Choy BK, Grall FT, Gu X, Libermann TA, Oettgen P, Goldring MB. ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol 2008; 251: 562-573.

Xu L, Peng H, Glasson S, Lee PL, Hu K, Ijiri K, Olsen BR, Goldring MB, Li Y: Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum 2007; 56:2663-2673

Goodwin JL, Farley ML, Swaim B, Goldring SR, Goldring MB, Bierbaum BE, Gray ML: Dual proline labeling protocol for individual "baseline" and "response" biosynthesis measurements in human articular cartilage. Osteoarthritis Cartilage 2008; 16:1263-1266.

Baldassarri M, Goodwin JS, Farley ML, Bierbaum BE, Goldring SR, Goldring MB, Burstein D, Gray ML: Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. J Orthop Res 2007; 25:904-912.

Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese E, Oettgen P, Libermann TA, Goldring MB. A novel role for GADD45b as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem 2005; 280:38544-38555.

Grall FT, Prall WC, Wei W, Gu X, Cho J-Y, Choy BK, Zerbini LF, Inan NS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J 2005;272:1676-87.

Facchini A, Borzi RM, Marcu KB, Stefanelli C, Olivotto E, Goldring MB, Flamigni F. Polyamine depletion inhibits NF-kB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-a. J Cell Physiol 2005 Sep; 204(3):956-63.

Tan L, Peng H, Osaki M, Choy BK, Auron PE, Sandell LJ, Goldring MB. Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1b. J Biol Chem 2003;278:17688-700.

Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor a in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum 2003;48:1249-60.

Osaki M, Tan L, Choy BK, Yoshida Y, Cheah KS, Auron PE, Goldring MB. The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-g-mediated inhibition in human chondrocytes: requirement for Stat1 a, Jak1 and Jak2. Biochem J 2003;369:103-15.

Selected Chapters, Review Articles and Editorials:

Goldring MB, Tsuchimochi K, Ijiri K. Control of chondrogenesis. J Cell Biochem 2006; 97:33-44.

Goldring MB, Sandell LJ. Transcriptional control of chondrocyte gene expression. In: J Buckwalter, M Lotz, J F Stoltz, editors: OA, Inflammation and Degradation: A Continuum. IOS Press, Amsterdam, 2007; 118-142.

Otero M, Goldring MB. Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther 2007; 9:220.

Goldring MB, Goldring SR: Osteoarthritis. J Cell Physiol 2007, 213:626-634

Arend WP, Goldring MB. The development of anti-cytokine therapeutics for rheumatic diseases [Review]. Arthritis Rheum 2008; 58:S102-S109.

Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis. 2008; 67(suppl III): iii75-iii82.

Goldring MB. Chapter 8G: Chondrocytes: Pathogenesis of Rheumatoid Arthritis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatoid Arthritis. Mosby Elsevier, Philadelphia, 2008; pp 151-162.

Goldring MB, Goldring SR. Chapter 1: Biology of the normal joint. In: Firestein GS, Budd RC Harris ED, McInnes IB, Ruddy S, Sergent JS, (eds): Kelley’s Textbook of Rheumatology, 8^th edition. Saunders Elsevier, Philadelphia. 2009; pp 1-22.

Goldring MB. Chapter 3: Cartilage and Chondrocytes. In: Firestein GS, Budd RC Harris ED, Ruddy S, Sergent JS, (eds): Kelley’s Textbook of Rheumatology, 8^th edition. Saunders Elsevier, Philadelphia. 2009; pp 37-69.

Hidaka C, Goldring MB. Regulatory mechanisms of chondrogenesis and implications for understandiing articular cartilage homeostasis. Curr Rheum Rev 2008; 4:136-147.

Onyekuma I, Goldring MB, Hidaka C. Chondrogenesis, joint formation, and articular cartilage regeneration. J. Cell. Biochem. 2009; 107:383-392.

Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic disease. Arthritis Res. Therapy 2009; 11(3):224.

For more publications, please see the PubMed listing.

Research Description

Laboratory of Cartilage Biology

Research in the Laboratory of Cartilage Biology is focused on defining the molecular and cellular mechanisms that lead to alterations in remodeling of cartilage in osteoarthritis and inflammatory joint diseases.