We are currently involved with several projects involving fracture healing. Using gene chip technology we are exploring the molecular mechanisms for fracture healing in order to improve clinical care for our patients with fractures.
Lieberman, J.R., Daluiski, A., and Einhorn, T.A. (2002) Current Concepts Review: The role of growth factors in the repair of bone: biology and clinical applications. J Bone Joint Surg Am. 84(6):1032-44.
Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM. (2001) Nat Genet. 27(1):84-8. Bone morphogenetic protein-3 is a negative regulator of bone density.
Daluiski, A., Yi, S.E., and Lyons, K.M. (2001) The molecular control of upper extremity development: implications for congenital hand anomalies. J. Hand Surgery [Am.] 26(1): 8-22.
Lieberman, J.R., Daluiski, A., Stevenson, S., Wu, L., McAllister, P., Lee, Y., Kabo, J.M., Finerman, G.A.M., Berk, A.J., and Witte, O.N. (1999) The effect of regional gene therapy with Bone Morphogenetic Protein-2 producing bone marrow cells on the repair of segmental femoral defects in rats. JBJS 81 (7): 905-917
Yi, S.E., Daluiski, A., Pederson, R., Rosen, V., and Lyons, K.M. (2000) The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127 (3): 621-630
Mintz MB, Sowers R, Brown KM, Hilmer SC, Mazza B, Huvos AG, Meyers PA, Lafleur B, McDonough WS, Henry MM, Ramsey KE, Antonescu CR, Chen W, Healey JH, Daluiski A, Berens ME, Macdonald TJ, Gorlick R, Stephan DA. (2005) An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. Cancer Res. 65(5):1748-1754
Ivkovic, S., Yoon, B.S., Popoff, S.N., Safadi, F.F., Libuda, D.E., Stephenson, R.C., Daluiski, A., and Lyons, K.M. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130(12):2779-2791
Engstrand, T., Daluiski, A., Bahamonde, M., Melhus, H., and Lyons, K.M. (2000) Transient production of bone morphogenetic protein 2 by allogeneic transplanted transduced cells induces bone formation. Human Gene Therapy 11(1): 205-11
Warden, C.H., Daluiski, A., Bu, X. D., Purcell Hyunh, D.A., DeMeester, C., Shieh, B. H., Puppione, D.L., Gray, R.M., Reaven, G.M., Chen, Y.-D.I., Rotter, J.I., and Lusis, A.J. (1993) Evidence for linkage of the apolipoprotein A II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans. Proc. Natl. Acad. Sci., 90: 10886-10890
Hyman, R.W., Frank, S., Warden, C.H., Daluiski, A., Heller, R., and Lusis, A.J. (1994) Quantitative trait locus analysis of susceptibility to diet-induced athersclerosis in recombinant inbred mice. Biochem. Genet. 32 (11/12): 397-407
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