Chitra Dahia, PhD

Selected Publications


Winkler T, Mahoney E, Sinner D, Wylie C, Dahia CL. (2014) Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse. Accepted in PLoS One, Jun 3;9(6):e9844; PMID:24892825

Dahia CL*, Mahoney E, Wylie C*. (2012) Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS ONE. 7(4): e35944. doi:10.1371/journal.pone.0035944 Epub 2012 Apr 27 * co-corresponding authors

Dahia CL, Mahoney E, Durrani A, Wylie C. (2011) Intercellular signaling pathways active during and after growth and differentiation of lumbar vertebral growth plate. Spine. Jun 15;36(14):1071-80.

Dahia CL, Sarkar MN, Rao AJ. (2011) A Comparative Analysis of Expression of Selected Genes during Induction of Differentiation in Neonatal Rats by Deprival of FSH or by Hyperthyroidism. The Open Andrology Journal. (3):14-24.

Dahia CL, Mahoney E, Durrani A, Wylie C. (2009) Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine. Mar 1;34(5):447-55.

Dahia CL, Mahoney E, Durrani A, Wylie C. (2009) Intercellular signaling pathways active during intervertebral disc growth, differentiation and aging. Spine. Mar 1;34(5):456-62.

Dahia CL, Rao AJ. (2009) Identification of Intracisternal A-Particle-Like Element as an FSH- regulated Transcript in Immature Rat Sertoli Cells. The Open Andrology Journal. (1):10-19.

Dahia CL, Petruz P, Hall SH, Rao AJ. (2008) Effect of deprivation of endogenous follicle stimulating hormone on rat epididymis: a histological evaluation. Reproductive BioMedicine Online. Sep;17(3) 331-7. 

Dahia CL, Rao AJ. (2006) Demonstration of follicle-stimulating hormone receptor in cauda epididymis of rat. Biology of Reproduction. Jul;75(1):98-106.

Dahia CL, Rao AJ. (2006) Regulation of FSH receptor, PKIbeta, IL-6 and calcium mobilization: Possible mediators of differential action of FSH. Molecular and Cellular Endocrinology. Mar 9;247(1-2):73-81.

Selected Books/Chapters

Chitra Lekha and A. J. Rao. Development of male contraceptives: approaches, associated problems and possible solutions; in “Hormone Biotechnology,” pp 3-16 2007, published by Daya Publishing House New Delhi, Ed. S.K.Maitra.

Research Description

Spine Development and Regeneration Lab

The main focus of Dahia lab is to understand the role of major cell signaling pathways, particularly Shh, Wnt, BMP and TGFß in postnatal development, differentiation, aging and degeneration of the intervertebral disc (IVD), and translate this to develop approaches for regeneration of the IVD and to treat lower back and disc related disorders.

Dahia researchIVDs are cartilagenous tissue present between each vertebra and its growth plates (GP). Each IVD consists of a central semi-liquid nucleus pulposus (NP), surrounded by a multi-layered annulus fibrosus (AF), and connected to the bodies of the adjacent vertebral bodies by cartilagenous end plates (EP). Together, these components form a strong joint that resists both tension and compression forces between vertebrae. Degenerative disc disease (DDD) is a major cause of lower back pain, and other neurological symptoms leading to a decreased quality of life. DDD is extremely common, affecting as many as one in seven people. However, how is it triggered is not known. The treatment costs are high, and often include surgical intervention. However, treatment is essentially palliative, since it treats the effects of disc degeneration rather than the causes.

Research in Dahia lab aims to identify the molecular mechanisms of postnatal growth, differentiation and aging of the IVD using mouse model system, and how these mechanisms are down-regulated, leading to age-related changes in the IVD. We have developed the mouse lumbar IVD as a model, and successfully shown that it can be used to identify the signaling pathways in the IVD that control postnatal growth and differentiation. We have found that during postnatal growth, the NP acts as a signaling center that controls both growth and differentiation of the postnatal IVD. NP cells express SHH, and blockade of Shh signaling both in vitro and in vivo shows that it is essential for cell proliferation and differentiation of the IVD. NP cells also express several WNT ligands, which are required to maintain Shh signaling in the IVD. Both these signaling pathways, and their downstream targets are down-regulated by the end of the growth period. Our studies show that Shh signaling, and the expression of differentiation markers, can be re-activated after the growth period by activation of canonical Wnt signaling. This suggests the potential of Shh and Wnt signaling pathways in regeneration of IVD.

The long-term goal is to identify potential biological approaches to therapy, using the same pathways that control IVD growth and differentiation during the early postnatal stages.

Candidates interested in PostDoctoral positions may email a detailed resume, electronic reprints of recent publications, and names and contact information for three references to dahiac@hss.edu

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Hayden-William Courtland, PhD

Contact Information

Office Locations

Caspary Research Building
541 East 71st Street
New York, NY 10021

Tel: 646.797.8448

Email Address

DahiaC@hss.edu

Mailing Address

Hospital for Special Surgery
535 East 70th Street
New York, New York 10021