Mathias P. Bostrom, MD

Appointments

Assistant Scientist Division of Research, Hospital for Special Surgery

Assistant Attending Orthopaedic Surgeon, Hospital for Special Surgery

Assistant Professor, Hospital for Special Surgery, Weill Medical College, Cornell University

Assistant Scientist Division of Research, Assistant Attending Orthopaedic Surgeon, Assistant Scientist Division of Research, Mineralized Tissue Section, Hospital for Special Surgery

 

Mathias P. Bostrom, MD is the author of the following articles on HSS.edu:

Selected Publications

  

For more publications, please see the PubMed listing.  

Research Description

The overall aim of my laboratory efforts continues to better understand the fundamental principles of bone healing and to use these principles in the development of methods to improve bone healing. Current projects include the use of a multigene assay to quantitatively describe the genetic cascade of growth factors and cytokines during the process of fracture healing. This work will be done in collaboration with Paul Cannon, Ph.D. at Roche Bioscience since he has access to gene chip technology. In addition to this work in the rat fracture model, we will also be collaborating with the scientists at Roche Bioscience in studying the gene expression in a number of human musculoskeletal tissues harvested during total joint arthroplasty procedures.

In collaboration with Nancy Camacho, Ph.D., we are also using Fourier transform infrared microscopy to better define the mineral and organic matrix characteristics of fracture callus. To achieve this goal we have recently developed a fracture model in the mouse and will be utilizing this model to determine the effects of alendronate treatment on the healing normal fractures as well as fractures in OIM mice. My collaboration with Dr. Camacho is also proceeding on developing a FTIR probe to study ultrastructural properties of cartilage and bone in human tissues harvested from total joint arthroplasties performed by me. In the future the use of FTIR methodology may prove to be of significant value in assessing the regeneration of cartilage through tissue engineering in both animal models and clinically. Thus a major thrust this upcoming year will be made with Dr. Camacho to assess the feasibility of using this technology in such a manner.

One of my major development projects over the last several years, in close association with Tim Wright Ph.D. and Marjolein van der Mullen Ph.D., has been the development of an in vivo cyclic loading device in rabbits to study the remodeling process of trabecular bone. This remodeling process has been studied with and without the use of exogenous osteogenic growth factors, and we are currently completing a series of experiments investigating the effects of magnitude, frequency and duration of load on trabecular bone. This work is being partially funded by a generous grant from the Oxnard Foundation and a development and feasibility grant from the NIH. The eventual goal is to improve bone adaptation around total joint implants, and the work will continue to proceed in this direction in the upcoming year with some modification of the loading device currently utilized with the goal of scaling it down to be used in rodents. This modification of the device will be made in collaboration with Dr. Per Aspenberg at the University of Lund in Lund, Sweden. With the anticipated arrival of a micro-CT device at HSS in the upcoming months work on this project as well as other collaborative bone projects will be significantly enhanced.

Clinically, I continue with efforts to establish RSA as outcome measure for total joint arthroplasty. The equipment for performing the studies is on site and we have obtained IRB approval to proceed with these studies. Finally, in the clinical arena, in collaboration with Dr. Kudryck at the New York Blood Center, I hope to be investigating the use of a novel fibrinogen assay to assess the role of the clotting cascade in patients with total hip arthroplasties.

Clinical Trials

• Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Knee Arthroplasty Cohort
• Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Hip Arthroplasty Cohort
• Evaluation of migration of a cementless, flat, tapered femoral component using RSA