Dr. Boskey studies the mechanism of biomineralization via analyses of the structure of mineral and matrix in health and disease, the role of matrix constituents in mineralization, and the development of novel methods to assess mineral and matrix properties. Human conditions of particular interest are: dystrophic calcifications, growth plate abnormalities, osteoporosis; osteoarthritis; and osteogenesis imperfecta. Matrix constituents studied include: phospholipids; collagen; noncollagenous proteins, and proteoglycans. Techniques for analysis include: the gel diffusion system for the study of in vitro mineralization, FT-IR microspectroscopy and imaging for the study of mineral and matrix properties, and wide angle x-ray diffraction.. The ultimate goal of the studies is to improve bone quality by providing insight needed for new therapies and tissue engineered products.
Starr Chair, Mineralized Tissue Research, Hospital for Special Surgery
Director, Mineralized Tissue Laboratory, Hospital for Special Surgery
Program Director, Musculoskeletal Integrity Program, Hospital for Special Surgery
Professor, Biochemistry, Weill Medical College of Cornell University
Professor, Graduate Program in Physiology, Biophysics, and Systems Biology, Weill Medical College of Cornell University
Professor, Graduate Center for Biomedical Engineering, City College of New York
Professor, Field of Biomechanical Engineering, College of Engineering, Cornell University
Pachman LM, Veis A, Stock S, Abbott K, Vicari F, Patel P, Giczewski D, Webb C, Spevak L, Boskey AL. Composition of calcifications in children with juvenile dermatomyositis: association with chronic cutaneous inflammation. Arthritis Rheum. 2006 Oct;54(10):3345-50.
Pourmand EP, Binderman I, Doty SB, Kudryashov V, Boskey AL. Chondrocyte apoptosis is not essential for cartilage calcification: Evidence from an in vitro avian model. J Cell Biochem. 2006 Aug 3; [Epub ahead of print]
Ling Y, Rios HF, Myers ER, Lu Y, Feng JQ, Boskey AL. DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res. 2005 Dec;20(12):2169-77.
Boskey AL, DiCarlo E, Paschalis E, West P, Mendelsohn R. Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation. Osteoporos Int. 2005 Dec;16(12):2031-8. Epub 2005 Aug 9.
Faibish D, Gomes A, Boivin G, Binderman I, Boskey A. Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia. Bone. 2005 Jan;36(1):6-12.
Gericke A, Qin C, Spevak L, Fujimoto Y, Butler WT, Sorensen ES, Boskey AL. Importance of phosphorylation for osteopontin regulation of biomineralization. Calcif Tissue Int. 2005 Jul;77(1):45-54.
MacDonald DE, Rapuano BE, Deo N, Stranick M, Somasundaran P, Boskey AL. Thermal and chemical modification of titanium-aluminum-vanadium implant materials: effects on surface properties, glycoprotein adsorption, and MG63 cell attachment. Biomaterials. 2004 Jul;25(16):3135-46.
Paschalis EP, Shane E, Lyritis G, Skarantavos G, Mendelsohn R, Boskey AL. Bone fragility and collagen cross-links. J Bone Miner Res. 2004 Dec;19(12):2000-4.
Silverman L, Boskey AL. Diffusion systems for evaluation of biomineralization. Calcif Tissue Int. 2004 Dec;75(6):494-501.
Verdelis K, Crenshaw MA, Paschalis EP, Doty S, Atti E, Boskey AL. Spectroscopic imaging of mineral maturation in bovine dentin. J Dent Res. 2003 Sep;82(9):697-702.
Boskey AL, Moore DJ, Amling M, Canalis E, Delany AM. Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res. 2003 Jun;18(6):1005-11.
Boskey AL, Paschalis EP, Binderman I, Doty SB. BMP-6 accelerates both chondrogenesis and mineral maturation in differentiating chick limb-bud mesenchymal cell cultures. J Cell Biochem. 2002;84(3):509-19.
Bonewald LF, Harris SE, Rosser J, Dallas MR, Dallas SL, Camacho NP, Boyan B, Boskey A. von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation. Calcif Tissue Int. 2003 May;72(5):537-47.
Atti E, Gomez S, Wahl SM, Mendelsohn R, Paschalis E, Boskey AL. Effects of transforming growth factor-beta deficiency on bone development: a Fourier transform-infrared imaging analysis. Bone. 2002 Dec;31(6):675-84.
.
