Assistant Scientist, Musculoskeletal Integrity Program, Hospital for Special Surgery
Assistant Professor, Department of Cell and Developmental Biology, Weill Cornell Medical College
Naobumi Hosogane, Zhiping Huang, Bernard A Rawlins, Xia Liu, Oheneba Boachie-Adjei, Adele L. Boskey, Wei Zhu. Stromal derived factor-1 regulates bone morphogenic protein 2- induced osteogenic differentiation of primary mesenchymal stem cells. The International Journal of Biochemistry and Cell Biology 2010. March 31. In press.
Wei Zhu, Bernard A Rawlins, Oheneba Boachie-Adjei, Baruch Frenkel, Adele L. Boskey, Lionel B. Ivashkiv, Carl P. Blobel. A novel regulatory role of SDF-1 signaling in BMP2-induced osteogenic differentiation of mesenchymal C2C12 cells. The Journal of Biological Chemistry 2007. 282(26):18676-85.
Wei Zhu, Jaehon Kim, Bernard A Rawlins, Oheneba Boachie-Adjei, Ronald G Crystal, Chisa Hidaka. Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro. Bone. 2006. 39(1): 61-71.
Hidaka C, Cunningham ME, Rodeo SA, Maher SA, Zhu W. Modern biologics used in orthopaedic surgery. Current Opinion on Rheumatology. 2006. 18(1):74-9.
Wei Zhu, Bernard A Rawlins, Oheneba Boachie-Adjei, Elizabeth Myers, Jun Arimizu, Eugene Choi, Jay R Lieberman, Ronald G Crystal, Chisa Hidaka. Combination bone morphogenetic protein-2 and –7 gene therapy enhances osteoblastic differentiation and spine fusion. The Journal of Bone and Mineral Research 2004.19(12):2021-32.
Wei Zhu, George AC Murrell, Jiahao Lin, Edith M Gardiner, Ashish D Diwan. Localization of nitric oxide synthases during fracture healing. The Journal of Bone and Mineral Research 2002.17(8): 1470-1477.
Wei Zhu, Ashish D Diwan, Jiahao Lin, George AC Murrell. Nitric oxide synthase isoforms during fracture healing. The Journal of Bone and Mineral Research 2001.16 (3): 535-540.
Ashish D Diwan, Min X Wang, Daniel Jang, Wei Zhu, George AC Murrell. Nitric oxide modulates fracture healing. The Journal of Bone and Mineral Research 2000.15(2): 342-351.For more publications, please see the PubMed listing.
Our long-term goal is to develop novel therapeutic strategies and methods to improve bone repair and regeneration for patients who suffer from fracture, trauma, arthritis, genetic or cancer-related bone defects. We focus on investigating molecular and cellular mechanisms that govern osteogenic differentiation and bone formation. Our major interested areas are: