Research Highlights: Transforming Science into Patient Care

Dr. Mary Goldring Named President of Orthopaedic Research Society

Dr. Mary Goldring, senior scientist at Hospital for Special Surgery (HSS) in New York City, has been named president of the Orthopaedic Research Society (ORS). The inauguration took place at the organization’s annual meeting on March 17 in New Orleans, with more than 2600 attendees. Learn More.

Scientists Identify New Target to Battle Rheumatoid Arthritis

A new study led by Xiaoyu Hu, M.D., Ph.D. at Hospital for Special Surgery identifies the mechanism by which a cell signaling pathway contributes to the development of rheumatoid arthritis (RA). In addition, the study provides evidence that drugs under development for diseases such as cancer could potentially be used to treat RA. Learn more

Osteoarthritis Summit Delineates Shortcomings of Research and Path Forward For Leading Cause of Disability in U.S.

A recent summit that brought together international multidisciplinary experts has provided a foundation for addressing what is the leading cause of disability in the United States: osteoarthritis. Consensus statements and analysis from the summit appear as part of a series of papers in Volume 8, Issue 1, of the Hospital for Special Surgery JournalLearn more

Chief Scientific Officer Named First Richard L. Menschel Research Chair at Hospital for Special Surgery

Steven R. Goldring, M.D., chief scientific officer, has been named the first Richard L. Menschel Research Chair at Hospital for Special Surgery. In addition to providing leadership for the HSS Research Division, Dr. Goldring’s research objective is to translate basic research into new therapies for people with mobility disorders, with a focus on expanding the Hospital’s clinical registries and advancing its Osteoarthritis Initiative. Learn More

HSS Receives $1 Million Gift for The Mary and Fred Trump Institute for Implant Analysis

Judge Maryanne Trump Barry, Donald Trump, Robert Trump, and Elizabeth Trump Grau have provided Hospital for Special Surgery with a $1 million gift in support of and to name the Institute for Implant Analysis in honor of their parents, the late Mary and Fred Trump. The Mary and Fred Trump Institute for Implant Analysis aims to innovate upon the science of joint reconstruction to improve the quality of life for millions of joint replacement patients around the world. The institute is under the direction of Timothy Wright, Ph.D., F.M., and Douglas Padgett, M.DLearn more

Research Excellence Attracts NIH Funding

Three new grants from the National Institutes of Health (NIH) support teams of Special Surgery surgeons and biomechanical engineers who are working to improve patient outcomes in joint and tissue replacement. At HSS, surgeons and engineers collaborate in the lab, where surgeons bring what they learn from their work with patients to the attention of biomechanical engineers. The grants support studies in knee function restoration, meniscus implants, and elbow replacements. Learn more

Dr. Adele Boskey 2010 Recipient of ORS/AOA Award for Lifetime Contributions to Orthopaedics

Adele L. Boskey, PhD received the Orthopaedic Research Society/ American Orthopaedic Association Alfred R. Shands, Jr. Award given annually in recognition of life-long achievement and contributions to orthopaedic research and furthering knowledge in the field of musculoskeletal disease. Learn more

Improving Patient Outcomes Through Registries

Registries provide the foundation for clinical trials, translational research, and treatment innovation. HSS has created more than 30 registries including the Hip, Knee and Shoulder Arthroplasty Registries, Sports Medicine and Shoulder Services ACL Registry, Center for Hip Preservation Registry, Autoimmune Disease Registry, and Scleroderma Registry. Read more and learn how to participate

Saving Pregnancies in Women with Lupus

Jane Salmon, MD is Principal Investigator on a multi-center NIH-funded research initiative, the PROMISSE study, to identify predictors of poor pregnancy outcomes in women with systemic lupus erythematosus (SLE). The study is providing insights on the genes and cellular pathways that can affect pregnancy in lupus patients and, potentially, cause miscarriage and preeclampsia in healthy women. Learn more

Senior Scientist with Experience in Autoimmunity and Inflammation Joins HSS

Alessandra Pernis, MD adds a new dimension to the Autoimmunity and Inflammation Program, bringing special expertise in acquired immunity. Dr. Pernis has made novel observations regarding the regulation of inflammation, which plays a critical role in diseases such as lupus and arthritis. She brings experience in animal and genetic models of rheumatoid arthritis and lupus, which will help us understand the origins of these diseases and develop therapies for them. Learn more

New Pathway Involved in Rheumatoid Arthritis – Potential for Therapeutic Approaches

Lionel Ivashkiv, MD is lead author of a study published in the journal Immunity identifying a cellular pathway involved in turning off inflammation that does not work properly in people with inflammatory arthritis. This is the first study to link this pathway to rheumatoid arthritis and could lead to the development of new therapeutic approaches to treat arthritis. Learn more

Osteoarthritis Initiative - A Multidisciplinary Approach

Osteoarthritis (OA), a painful and often debilitating joint disease, is a leading cause of disability and the most common underlying condition of patients seeking treatment at Hospital for Special Surgery. While the symptoms of OA are well-known, the root causes of the disease remain unclear. Staffed with the world’s best orthopedic surgeons, musculoskeletal-trained radiologists, biomedical engineers, and basic scientists, and with patients with a wide range of OA symptoms to learn from, HSS is uniquely situated to lead in OA research. Learn more

Biomarker Could Help Tailor Treatment for Rheumatoid Arthritis

Investigators have identified a biomarker that could help doctors select patients with rheumatoid arthritis (RA) who will benefit from therapy with drugs such as Enbrel, a tumor necrosis factor (TNF)-antagonist drug. While these drugs bring relief to many RA patients, they are not highly effective in 30% to 50% of patients. The study, led by Mary K. Crow, MD, along with researchers at Hospital for Special Surgery in collaboration with rheumatologists at the University of Southern California, was published in the journal Arthritis & Rheumatism. Learn more

Research Grants

HSS currently receives more than $14 million annually in grants from the National Institutes of Health (NIH) to support basic and clinical research activities. In addition, research is supported by grants from the Arthritis Foundation, Orthopaedic Research and Education Foundation, Alliance for Lupus Research, Rheuminations, Inc., Lupus Clinical Trials Consortium, Inc., and others. Learn more

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