Study Methodologies for Osteoarthritis: Clinical Trials and Tribulations

Jeffrey N. Katz, MD, MSc
Harvard Medical School, Brigham and Women’s Hospital, Harvard School of Public Health, Boston, MA


Introduction

Clinical trials represent the most rigorous approach to evaluating the efficacy of interventions. The clinical trial is a relatively young methodology, used rarely until the middle of the twentieth century. Most clinical trials evaluate medications. In fact a review of clinicaltrials.gov in 2011 indicated that of more than 100,000 registered trials, over 70% were drug trials. The remainder was divided among devices, surgery, and behavioral and educational interventions. While drug trials are important for development of therapeutics in osteoarthritis, trials of surgery, devices, and educational and behavioral interventions are critical as well.

This article appears in HSS Journal: Volume 8, Number 1.
View the full article at springerlink.com.

About the HSS Journal

HSS Journal, an academic peer-reviewed journal published three times a year, February, July and October. The Journal accepts and publishes peer reviewed articles from around the world that contribute to the advancement of the knowledge of musculoskeletal diseases and disorders.


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