Osteoarthritis as a Whole Joint Disease

A. R. Poole, PhD, DSc,
Department of Surgery, McGill University, Montreal, Canada


Introduction

Osteoarthritis (OA) is a disease that causes pain and disability. It is usually slowly progressive, and cartilage degeneration with a loss of joint space (a common measure of progression) is often not continuous, as evidenced by numerous clinical trials and longitudinal studies. The emphasis of research and clinical trials has been on the degeneration of articular cartilage, being required with synovial fluid for the almost frictionless articulation and a key determinant, with the meniscus, of knee joint space on radiographic analysis. However, emerging evidence exists that all or almost all joint tissues are involved and/or affected by this degenerative process.

This article appears in HSS Journal: Volume 8, Number 1.
View the full article at springerlink.com.

About the HSS Journal

HSS Journal, an academic peer-reviewed journal published three times a year, February, July and October. The Journal accepts and publishes peer reviewed articles from around the world that contribute to the advancement of the knowledge of musculoskeletal diseases and disorders.


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