This case exemplifies the diagnostic challenges faced when evaluating patients with hypereosinophila. It also demonstrates the potential severity and fatal consequences of cardiac involvement in CSS. The patient’s complex infectious history complicated the decision to initiate disease-modifying treatment. Randomized clinical trials and studies of investigational treatments are warranted to improve outcomes in CSS patients.
RS receives consulting and research funding from RocheGenentech. All other author certifies that he or she has no commercial associations (e.g., consultancies, stock ownership, equity interest, patent/ licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article. Each author certifies that his or her institution has approved the reporting of the case, that all investigations were conducted in conformity with the ethical principles of research, and that informed consent for participating in the study was obtained.