Bone Morphogenic Proteins: Applications in Spinal Surgery

HSS Journal


James C. Farmer, MD

James C. Farmer, MD

Associate Attending Orthopaedic Surgeon, Hospital for Special Surgery
Associate Professor of Orthropedic Surgery, Weill Cornell Medical College

Harvinder S. Sandhu, MD

Harvinder S. Sandhu, MD

Associate Attending Orthopaedic Surgeon, Hospital for Special Surgery
Assistant Scientist, Research Division, Hospital for Special Surgery
Associate Professor of Orthopedic Surgery, Weill Cornell Medical College

Gerard K. Jeong, MD
Spine and Scoliosis Fellow
Hospital for Special Surgery

Abstract
The prospect of predictable and reliable osteogenesis without the need for secondary bone grafting to treat a wide spectrum of spinal disorders is tremendously appealing. Recombinant human bone morphogenic proteins (rhBMP) have been the subject of extensive basic science, animal, and clinical research as a potential therapeutic modality to promote bony fusion. Animal studies and prospective, randomized clinical trials have demonstrated the efficacy of rhBMPs as an adjunct or substitute to autogenous bone graft in the specific treatment of certain spinal conditions. The future role of rhBMPs in spinal surgery applications remains to be determined and will be dependent upon future investigations evaluating 1) the efficacy in a variety of spinal conditions and environments, 2) the optimal dose and delivery system, 3) the long-tem safety profile (immunogenicity, antibody formation), and 4) the cost effectiveness of these therapeutic growth factors.

This article appears in HSS Journal: Volume 1, Number 1.
View the full article at springerlink.com.


About the HSS Journal
HSS Journal, an academic peer-reviewed journal, is published twice a year, February and September, and features articles by internal faculty and HSS alumni that present current research and clinical work in the field of musculoskeletal medicine performed at HSS, including research articles, surgical procedures, and case reports.

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