Jane E. Salmon, MD

Dr. Jane Salmon is Professor of Medicine and Professor of Obstetrics and Gynecology at Weill Cornell Medical College and the Collette Kean Research Professor at Hospital for Special Surgery.

Dr. Salmon graduated magna cum laude from New York University and earned a medical degree in 1978 from the College of Physicians and Surgeons of Columbia University, where she was the first woman enrolled in their Medical Scientist Training Program. She completed training in internal medicine at The New York Hospital and in rheumatology at Hospital for Special Surgery, and has been an HSS faculty member since 1983. Dr. Salmon has served on the Board of Directors of the American College of Rheumatology and as Councilor of the Clinical Immunology Society. She has served on the NIH Advisory Boards for the North American Rheumatoid Arthritis Consortium and the Lupus Multiplex Registry and was co-editor of Arthritis and Rheumatism. At Hospital for Special Surgery, she is a co-Director of the Mary Kirkland Center for Lupus Research, Director of the SLE APS Center of Excellence, Director of the FOCIS Center of Excellence, and Director of the Lupus Registry and Repository.

Dr. Salmon’s research has focused on elucidating mechanisms of tissue injury in lupus and other autoimmune diseases. Her basic and clinical studies have expanded our understanding of pregnancy loss and organ damage in SLE and the determinants of disease outcome in lupus patients with nephritis, pregnancy, and cardiovascular disease.

Appointments

Attending Physician, Hospital for Special Surgery
Collette Kean Research Chair, Hospital for Special Surgery
Director, SLE APS Center of Excellence, Hospital for Special Surgery
Senior Scientist, Hospital for Special Surgery
Co-Director, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery
Director of the Lupus Registry and Repository, Hospital for Special Surgery
Professor of Medicine, Weill Cornell Medical College
Professor of Medicine in Obstetrics and Gynecology, Weill Cornell Medical College
Professor, Graduate Program in Immunology, Weill Cornell Graduate School of Medical Sciences

Specialty

Rheumatology
Internal Medicine

Special Expertise

Systemic Lupus Erythematosus
Antiphospholipid Syndrome
Rheumatoid Arthritis

Awards

"Best Doctors in New York," New York magazine, 2009
American Association of Physicians 2008
Carol Nachman Prize in Rheumatology, 2007
Eric Bywaters Memorial Lecture, Imperial College of London, 2007
Edmund L. Dubois, MD, Memorial Lectureship Award, American College of Rheumatology, 2004

Affiliations

FOCIS Centers of Excellence Committee
Scientific Programme Committee, European League Against Rheumatism (EULAR)

Specialized Centers

• Mary Kirkland Center for Lupus Research
  

Education

MD, Columbia University College of Physicians and Surgeons, New York

Residency

The New York Hospital, New York, New York

Fellowship

Hospital for Special Surgery, Fellow in Rheumatic Diseases

Certification

Rheumatology
Internal Medicine

State Licensure

New York  

Jane E. Salmon, MD has contributed to the following articles on HSS.edu:

Selected Publications

Qing X, Redecha PB, Burmeister MA, Tomlinson S, D’Agati VD, Davisson RL, Salmon JE. Targeted Inhibition of Complement Activation Prevents Features of Preeclampsia in Mice. Kidney Intl, 79: 331-9, 2011.

Lynch AM, Salmon JE. Dysregulated Complement Activation as a Common Pathway of Injury in Preeclampsia and Other Pregnancy Complications. Placenta 31: 562-567, 2010

Roman MJ, Crow MK, Lockshin MD, Devereux RB, Paget SA, Sammaritano, L, Levine DM, Davis A, Salmon JE. Rate and Determinants of Progression of Atherosclerosis in Systemic Lupus Erythematosus. Arthritis Rheum 56: 3412-19, 2007.

Roman MJ, Salmon JE. Cardiovascular Manifestations of Rheumatologic Diseases. Circulation 116: 2346-2355, 2007.

Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement Activation Induces Dysregulation of Anglogenic Factors and Causes Fetal Rejection and Growth Restriction. J Exp Med 203: 2165-2175, 2006.

Roman M, Moeller E, Davis A, Paget SA, Crow MK, Lockshin MD, Sammaritano L, Devereux RB, Schwartz JE, Levine DM, Salmon JE. Preclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis: Prevalence and Associated Factors. Ann Intern Med 144: 249-256, 2006.

Girardi G, Redecha PB, Salmon JE. Heparin Prevents Antiphospholipid Antibody-induced Fetal Loss by Inhibiting Complement Activation. Nat Med 10: 1222-6, 2004.

Roman, MJ, Shanker B-A, Davis A, Lockshin MD, Sammaritano L, Simantov R, Crow MK, Schwartz JE, Paget SA, Devereux RB, Salmon JE. Prevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus Erythematosus. New Engl J Med 349: 2399-406, 2003.

Girardi G, Berman J, Redecha P, Spruce L, Thurman JM, Kraus D, Hollmann TJ, Casali P, Caroll MC, Wetsel RA, Lambris JD, Holers VM, Salmon JE. Complement C5a Receptors and Neutrophils Mediate Fetal Injury in the Antiphophospholipid Syndrome. J Clin Invest 112: 1644-54, 2003.

Salmon JE, Millard SS, Schachter LA, Arnett FC, Ginzler EM, Gourley MF, Ramsey-Goldman R, Kimberly RP: FcgRIIA alleles are heritable risk factors for lupus nephritis in African Americans. J Clin Invest 97: 1348-1354, 1996.

For more publications, please see the PubMed listing.

Selected Books/Chapters

Lockshin MD, Salmon JE, Erkan D. Pregnancy and Rheumatic Diseases. In: Maternal-Fetal Medicine (6th edition), edited by RK Creasy and R Resnik Elsevier Health Sciences, Philadelphia, pp1079-1087, 2009.

Erkan D, Salmon JE, Lockshin MD. Antiphospholipid Syndrome. In: Kelley’s Textbook of Rheumatology, 8th Edition, edited by Ruddy S, Harris ED, Jr., Sledge C. Elsevier Saunders, Philadelphia, pp1301-1310, 2008.

Salmon JE. Mechanisms of Immune-mediated Injury. In: Cecil Textbook of Medicine (23rd edition), edited by L Goldman and D Ausiello, Saunders, Philadelphia, pp 266-270, 2008.

Salmon JE, Pricop L, D’Agati V: Immunopathology of SLE. In: Rheumatology 4th Edition, edited by MC Hochberg, AJ Silman, JS Smolen, ME Weinblatt, M Weisman. Mosby, London, pp 1217-1235, 2008.

Selected Presentations

Soderberg Prize Symposium, Swedish Society of Medicine, Stockholm, 2010
Theodore E. Woodward Award, American Clinical and Climatological Association, 2007
Carol Nachman Prize in Rheumatology, Premier International Award Recognizing Innovative Research in Rheumatology, 2007
Arthur DeGraff Lecture, New York University School of Medicine, 2007
Eric Bywaters Memorial Lecture, Imperial College of London, 2007
Edmund L. Dubois, MD, Memorial Lectureship Award, American College of Rheumatology, 2004
Dr. Jacob Probstein Endowed Lecture in Obstetrics and Gynecology, Washington University in St. Louis, 2004  

Research Description

Inflammatory Effector Mechanisms Laboratory

The goal of our research is to identify determinants of disease phenotype in systemic lupus erythematosus (SLE) and related diseases, and to thereby identify targets for therapy. Our laboratory approach is to study effector function and mechanisms of tissue injury. In SLE and other autoimmune diseases, autoantibodies and immune complexes trigger inflammation and organ damage through receptors for Ig (FcgR) and complement activation products. These mechanisms are currently studied in three projects.

• The Role of Complement Activation in Antiphospholipid Antibody-induced Pregnancy Loss and Thrombosis
• Accelerated Cardiovascular Disease in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Prevalence and Responsible Mechanisms

Research Interests

Systemic Lupus Erythematosus
Antiphospholipid Syndrome
Pregnancy in Autoimmune Patients
Cardiovascular Disease in Autoimmune Patients

Clinical Trials

• PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
• Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE)
• Autoimmune Disease Registry and Repository
• Scleroderma Registry