Dale J. Lange, MD, is the Chairman of Neurology and Neurologist-in-Chief at Hospital for Special Surgery and a Professor of Neurology at Weill Medical College of Cornell University. He is an Attending Physician both at Hospital For Special Surgery and NewYork Presbyterian Hospital‘s Weill Cornell campus. He is also the current President of the New York State Neurological Society.
Dr. Lange has devoted his entire clinical career to caring for patients with disorders of peripheral nerve and muscle disease and performing research investigating novel therapies and new ways to diagnose and treat patients with weakness and impaired mobility.
Dr. Lange received his medical degree from New York Medical College and completed his internship in medicine at Albany Medical Center. He completed his residency in neurology at the Tufts New England Medical Center in Boston, MA, and then became the Clinical Fellow of the Muscular Dystrophy Association in EMG and Neuromuscular Disease at the Neurological Institute at the Columbia Presbyterian Medical Center in New York.
Dr. Lange has served on the faculties of the College of Physicians and Surgeons of Columbia University and the Mount Sinai School of Medicine, where he was the Director of the Division of Neuromuscular Disease. Dr. Lange was also Chief of Neurology at the James J. Peters Veterans Administration Hospital in the Bronx.
He currently is the Director of the MDA/ALS Center at Weill Cornell Medical College, which is a multidisciplinary care program for patients with all forms of muscular dystrophy and ALS. He also directs the ALS Program at HSS, a multidisciplinary care program devoted to the care of patients and families with ALS.
Dr. Lange’s clinical practice is focused primarily on the diagnosis and management of diseases of nerve and muscle, including motor neuron disease (ALS), peripheral neuropathy (GBS, CIDP, diabetic, toxic, metabolic neuropathies), neuromuscular junction disorders (myasthenia gravis, Lambert-Eaton myasthenic syndrome, and botulism), and myopathies (polymyositis, inclusion-body myositis, and muscular dystrophies). He also performs nerve conduction, needle EMG, and single-fiber EMG studies to evaluate patients with focal and generalized neuromuscular disorders.
Dr. Lange has been engaged in clinical and basic science research throughout his career. He has worked on many projects bringing ideas from bench to bedside, the model for translational research. His research interests include designing, implementing, and managing clinical trials for patients with ALS and other neuromuscular diseases. He is involved in several clinical trials, both investigator-initiated as well as multi-center trials in ALS, peripheral neuropathy, and muscular dystrophy.
Dr. Lange is the author of more than 90 peer reviewed articles and chapters in textbooks. He has been invited to lecture, both nationally and internationally, on topics related to his research in neuromuscular disease.
Dr. Lange sees patients with complaints related to nerve and muscle disease as well as select general neurological conditions in his office at Hospital for Special Surgery.
Zhao Z, Lange, DJ, Voustiaiouk A, MacGrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neuroscience 2006;7:29-58.
Pasinetti GM, Ungar LH, Lange DJ, Yemul S, Deneg H, Yuan X, Brown RH, Cudkowicz ME, Newhall K, Peskind E, Marcus, S, Ho, L. Identification of potential CSF biomarkers in amyotrophic lateral sclerosis. Neurology 2006; 66:1218-1222.
Lange DJ, DeAngelis T. Sivak M. Single fiber EMG shows terminal axon dysfunction in Miller Fisher Syndrome. Muscle Nerve 2006; 34:232-234.
Lange DJ, Lechtzin N, Davey C, Gelinas D, Heiman-Patterson T, David W, Becker B, Mitsumoto H. A Randomized, controlled trial of high frequency chest wall oscillation in ALS. Neurology 2006; 26: 991-997.
Lange DJ, Weimer L, Gooch CL, Lovelace RE, Trojaborg W, Rowland LP. Multifocal Motor Neuropathy with Conduction Block: Slow But Not Benign. Archives of Neurology. 2006; 63:1778-1781.
Lechtzin N, Lange DJ, Davey C, David W, Heiman-Patterson T, Gelinas D, Becker B, Kimball R, Mitsumoto H. Measures of dyspnea in patients with amyotrophic lateral sclerosis. Muscle Nerve 2007; 35: 98-102.
Voustianiouk A, Seidel G, Panchal J, Czaplinski A, Yen A, Appel SH, Lange DJ. ALSFRS and Appel ALS scores: Discordance with disease progression. Muscle Nerve 2008; 37:668-672.
Zhao, Z, Lange DJ, Ho, L, Bonini S, Shao, B, Salton SR, Thomas S, Pasinetti GM. VGF is a novel biomarker associated with weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis. Int J Med Sci 2008; 5: 92-99.
van der Ploeg AT, Clemens PR, Corzo D, Escolar D, Florence J, Groeneveld GJ, Herson S, Kishnani PS, Laforet P, Lake SL, Lange DJ, Leshner RT, Mayhew JE, Morgan C, Nozaki K, Park DJ, Pestronk A, Rosenbloom B, Skrinar A, van Capelle CI, van der Beek NA, Wasserstein M, Zivkovic SA. A Randomized Study of Alglucosidase Alfa in Late-onset Pompe Disease. N Eng J Med. 2010; 362:1396-1406.
Lange DJ, Nijar R, Voustianiouk A, Siedel G, Panchal J, Wang A. Do A-waves help predict intravenous immunoglobulin response in multifocal motor neuropathy without block? Muscle Nerve 2011; 43:537-542.
Shtilbans A, Choi SG, Fowkes ME, Khtrov G, Shahbazi M, Ting J, Zhang W, Sun Y, Sealfon SC, Lange DJ. Differential gene expression in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2011 12:250-256.For more publications, please see the PubMed listing.
Lange DJ, Trojaborg W. Electromyography and Nerve Conduction Studies. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 73-77.
Lange DJ, Latov N, Trojaborg W. Acquired Neuropathies. In Merritt’s Textbook of Neurology. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 613-633.
Lange DJ, Trojaborg W, Rowland LP. Peripheral and Cranial Nerve Lesions. In: Merritts Textbook of Neurology. Rowland LP, ed, Tenth edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2000: 436-434.
Kissel JT, Amato AA, Barohn RJ, Iannaccone ST, Lange DJ, Mendell JR. Muscle Disease. Continuum - Lifelong Learning in Neurology, 2000; 6:1-227.
Lange DJ, Tolunsky, E. Infections of Peripheral Nerve. Neuromuscular Function and Disease. Electrodiagnostic Medicine. Brown WF, Bolton C, Aminoff M, eds. Lippincott Williams & Wilkins Philadelphia, PA. 2002; 1251-1253.
Gooch C, Lange DJ, Trojaborg W. Peripheral and Cranial Nerve Lesions. In: Rowland LP, ed, Eleventh edition. Lippincott Williams & Wilkins, Philadelphia, PA. 2005: 523-543.
Robinson-Papp J, Lange DJ. Immune Mediated Demyelinating Neuropathies. Up To Date. 2008 (in press).
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