Research

Synoival Pathology in Patients undergoing Hip Arthroscopy for Impingement and/or Labral Pathology: Role in Clinical Pre-Operative Symptoms and Post-Operative Outcomes

IRB Number: 12010

Institutional Review Board, Hospital for Special Surgery

March 01, 2012

The safety of study participants is our top priority. The trial is approved and periodically reviewed by an Institutional Review Board (IRB), which includes doctors, administrators, ethicists, and members of the general public. The safety of clinical trials is reviewed by the U.S. Food and Drug Administration.

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Principal Investigator

Bryan Kelly, MD

Co-Investigators

Edward F. Di Carlo, MD
Struan H. Coleman, MD, MPH
Steven R. Goldring, MD
Stephen Lyman, MD
Hollis G. Potter, MD
Anil S. Ranawat, MD
Ernest L. Sink, MD

Summary

This study will establish a tissue registry using tissues that would otherwise be discarded at the time of surgery (synovial fluid and joint tissues, including cartilage, bone, synovium, and labrum).  The purpose of the registry is to investigate the role of synovial inflammation in pre-operative symptoms and post-operative outcomes in patients undergoing surgery for femoro-acetabular impingement and/or acetabular labral pathology.

An estimated 100 subjects per year will be enrolled into this registry.  The primary outcome will be the Hip Outcomes Score and secondary outcomes will include the Modified Harris Hip Score and the ihot33.  These will be measured at 6 months and 2, 5 and 10 years after surgery as part of the existing Hip Preservation Registry (IRB #10036). Correlating these outcomes to the synovial pathology will allow us to investigate the role of synovial inflammation on post-surgical outcomes.

Inclusion/Exclusion Criteria

Inclusion
  Age 16-45
Arthroscopic/surgical evidence of impingement and/or labral pathology without or with   
   synovial fluid effusion, inflamed synovium, and cartilage damage.

Exclusion
History of tumor  
Reciprocal focal Grade 4 cartilage wear
Infection in the index joint  
Advanced arthritis

Contact Information

Erin Magennis
646.797.8767
magennise@hss.edu



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