Research

Clinical Trials by Condition

Please find clinical trials at HSS listed by the following conditions:

Non-orthopedic and non-rheumatologic clinical trials are conducted at Weill Cornell Medical College, an affiliate of Hospital for Special Surgery. Learn more

APS (Antiphospholipid Syndrome)

IRB#
Clinical Trial
Principal Investigator
11179
A Prospective, Randomized-Controlled Trial Comparing Hydroxychloroquine in the Primary Thrombosis Prophylaxis of Persistently Antiphospholipid Antibody (aPL) Positive but Thrombosis-free Patients without Systemic Autoimmune Diseases.
Doruk Erkan, M.D.
11180
APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical Database and Repository.
Doruk Erkan, M.D
12186
Comparison of Gut Commensal Bacteria between Persistently Anti-beta2 Glycoprotein-1 Positive Patients and Antiphospholipid Antibody Negative Patients
Doruk Erkan, MD
28005
Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome
Doruk Erkan, MD
28023
Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients
Doruk Erkan, MD
10130
Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without Systemic Lupus Erythematosus
Doruk Erkan, MD
27022
RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS)
Doruk Erkan, MD
22122
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
95004
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD

Arthritis

IRB#
Clinical Trial
Principal Investigator
11095
Studies of Immune Deregulation in Patients with Rheumatoid Arthritis, Polymyalgia Rheumatica and Vasculitis
Alessandra B. Pernis, MD
25097
Arthritis Intervention Programs for People with Arthritis and Related Disease
Laura Robbins, DSW
12046
Retrospective Review of Education Programs for People with Musculoskeletal Disorders
Laura Robbins, DSW
11096
Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry38880
Thomas J.A. Lehman, MD
23034
Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls
Lisa A. Mandl, MD, MPH
23108
Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis
Robert G. Marx, MD
26043
A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial
Lisa A. Mandl, MD, MPH
26035
Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial
Lisa A. Mandl, MD, MPH
25022
Quantitative Assessment of the Synovial Vascularity in Early Inflammatory Arthritis
Lisa A. Mandl, MD, MPH
24067
Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC
Lisa C. Vasanth, MD
22007
Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients
Geoffrey Westrich, MD

Arthroplasty

IRB#
Clinical Trial
Principal Investigator
26117
Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Shoulder Arthroplasty Cohort
Lawrence V. Gulotta, MD
27027
Vitamin D Status Among Trauma Patients; Acute Fractures/Non-unions vs. Primary Joint Arthroplasty (control population)
Joseph M. Lane, MD
26073
Evaluation of migration of a cementless, flat, tapered femoral component using RSA
Edwin P. Su, MD
22007
Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients
Geoffrey Westrich, MD
28041
The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty
Stavros G. Memtsoudis, MD
26115
Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength
Bryan J. Nestor. MD
26079
Deep Vein Thrombosis (DVT) Prevention in Total Hip Replacement: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH)
Douglas E. Padgett, MD
21072
The Genetic Factor: Identifying Patients at High Risk for Developing Pulmonary Embolism (PE) After Orthopedic Surgery (Upper Extremity, Spine, THR, TKR) Using A Molecular Screening Test
Geoffrey H. Westrich, MD

Foot and Ankle Conditions

Ankle Conditions

IRB#
Clinical Trial
Principal Investigator
2012-042
Duration of Analgesia after Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine
Jacques T, Ya Deau, MD, PhD
11066
Randomized Controlled Trial of Platelet-Rich Plasma Versus Whole Blood in the Treatment of Chronic Mid-Portion Achilles Tendinosis
John G. Kennedy, MD
11040
A Prospective, Randomized, Controlled, Multi-Center, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of Augment™ Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions
Andrew J. Elliott, MD
28086
Does Pregabalin Reduce Pain after Ankle Surgery?
Jacques T YaDeau, MD, PhD

Foot Conditions

IRB#
Clinical Trial
Principal Investigator
2012-056
Analgesia after Total Knee Arthroplasty: Peri-Articular Injection vs. Epidural + Femoral Nerve Blockade
Jacques T. YaDeau, MD, PhD
2012-052
Pharmacodynamics of Ultrasound Guided Popliteal Catheter Infusion after Foot and Ankle Surgery
Daniel B. Maalouf, MD, MPH
2012-042
Duration of Analgesia after Popliteal Fossa Nerve Blockade: Effects of Dexamethasone and Buprenorphine
Jacques T, Ya Deau, MD, PhD
11066
Randomized Controlled Trial of Platelet-Rich Plasma Versus Whole Blood in the Treatment of Chronic Mid-Portion Achilles Tendinosis
John G. Kennedy, MD
11040
A Prospective, Randomized, Controlled, Multi-Center, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of Augment™ Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions
Andrew J. Elliott, MD
28019
Early Mobilization following Adult Acquired Flatfoot Deformity Reconstruction
Jonathan T. Deland, M.D.
10015
Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study
Allison M. Brown, PT, MA
28021
In Vivo Radiographic Validation of Novel EMED Plantar Pressure Masking Algorithm
Jonathan T. Deland, MD
26071
Development of a Geometric Foot Model: A Tool for Clinical Decision Making
Howard J. Hillstrom, PhD

Knee Conditions

IRB#
Clinical Trial
Principal Investigator
14081
Arthroscopic Treatment of Symptomatic Discoid Meniscus in Children: Long-term Follow-up
Daniel W. Green, MD, MS, FAAP, FACS
2012-002
Postoperative Analgesia comparing Subsartorial Saphenous Nerve Block with and without Dexamethasone in ACL Reconstruction
Mary F. Chisholm, MD
2012-031
Saphenous (Adductor Canal) Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty: A Novel Approach for Postoperative Analgesia
David H. Kim, MD
2012-051
Effects of Pregabalin on Pain after Total Knee Arthroplasty: A Dose-Response Study
Jacques T. YaDeau, MD, PhD
2012-034
The Effect of Postoperative Blood Transfusions on Muscle Tissue Oxygenation after Hip and Knee Arthroplasty.
Stavros G. Memtsoudis, MD, PhD
28008
Lower Extremity Realignment Therapy for the Treatment of Medial Knee Osteoarthritis- A Pilot Study
Howard J. Hillstrom, PhD
26035
Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial
Lisa A. Mandl, MD, MPH
27142
A Randomized Comparison of NeoCart® to Microfracture for the Repair of Articular Cartilage Injuries in the Knee
Riley J. Williams III, MD
11079
Catheter Lateralization by Electrical Stimulation during Epidural Anesthesia
Nigel E. Sharrock, MD
27127
Prospective Study of the effects of Femoral Nerve Block on Quadriceps Strength Post ACL Allograft Reconstruction
Thomas L. Wickiewicz, MD
22129
Bone Tunnel Widening Following ACL (Anterior Cruciate Ligament) Reconstruction
Scott Rodeo, MD
28041
The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty
Stavros G. Memtsoudis, MD
10122
Revision Anterior Cruciate Ligament Reconstruction in Adolescents
Frank A. Cordasco, MD
26115
Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength
Bryan J. Nestor. MD

Lupus

IRB#
Clinical Trial
Principal Investigator
11113
A Phase 2B, Dose Ranging Study to Evaluate the Efficacy and Safety of Sifalimumab in Adults with SLE
Kyriakos A. Kirou, MD, DSc, FACP
10117
A Phase 1 Double Blind, Randomized, Single Ascending Dose Study of the Safety and Tolerability of MEDI 570 in SLE
Kyriakos A. Kirou, MD
10130
Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without Systemic Lupus Erythematosus
Doruk Erkan, MD
11141
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE) (ILLUMINATE-2)
Doruk Erkan, M.D.
13219
A Phase 3/4, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006) in Adult Subjects of Black Race with Systemic Lupus Erythematosus (SLE)
Kyriakos A. Kirou, MD, DSc, FACP
14008
Focus Groups to Gather Patient Preferences about the HSS Smartphone Application for Systemic Lupus Erythematosus
Alana B. Levine, MD
22122
PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
93029
Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE)
Jane E. Salmon, MD
95004
Autoimmune Disease Registry and Repository
Jane E. Salmon, MD

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.

Neurological Disorders

ALS (Amyotrophic Lateral Sclerosis)

IRB#
Clinical Trial
Principal Investigator
13150
Multi-center, randomized controlled study of the NeuRx® Diaphragm Pacing System™ in participants with Amyotrophic Lateral Sclerosis (ALS)
Dale J. Lange, MD
10062
Safety and Efficacy of SOD1 Inhibition by Pyrimethamine in Sporadic ALS
Dale J. Lange, MD
29084
Safety and Efficacy of SOD1 Inhibition by Pyrimethamine in Familial ALS
Dale J. Lange, MD

Shoulder Conditions

IRB#
Clinical Trial
Principal Investigator
11195
Scapular Kinematics of Healthy Controls and Individuals with Asymptomatic Rotator Cuff Tears: Reliability and Group Comparison in Older Adults.
Andreas Kontaxis, PhD
27020
Intra-articular Corticosteroid Injection for Idiopathic Adhesive Capsulitis of the Shoulder
Jennifer L. Solomon, MD
11035
Rotator Cuff Repair: A Prospective Randomized Trial Evaluating Two Commonly Performed Techniques
Frank A. Cordasco, M.D.
27122
Supraclavicular vs Interscalene Brachial Plexus Block for Shoulder Surgery
Christopher A DiMeo, MD
27071
Adhesive Capsulitis: A Quantitative Analysis of Myofibroblast Proliferation
Jo A Hannafin, MD
27050
The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability
Sherry I. Backus PT, DPT, MA

Spine Conditions

IRB#
Clinical Trial
Principal Investigator
26118
Genetic Mapping Studies of Adolescent Idiopathic Scoliosis
Cathleen L. Raggio, MD
27016
Osteogenic Differentiation of Human Mesenchymal Stem Cells
Wei Zhu, Ph.D.
26033
Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures
Joseph M. Lane, MD

Skeletal Dysplasias

IRB#
Clinical Trial
Principal Investigator
23125
The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry
Cathleen Raggio, MD
25039
A Randomized Double Blind Placebo Controlled Multi-Center Parallel Group Study of One Year Duration Followed by Two Years of open-label Treatment to Determine the Safety and Efficacy of Orally Administered 2.5 mg or 5.0 mg Daily Risedronate
Cathleen L. Raggio, MD

Scleroderma

IRB#
Clinical Trial
Principal Investigator
13224
The LOTUSS Trial: An Open-Label, Randomized, Phase 2 Study of the Safety and Tolerability of Pirfenidone When Administered to Patients With Systemic Sclerosis-Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)
Robert F. Spiera, MD
13004
ASCI: A Randomized, Double-blind, Placebo-controlled, Phase II Multicenter Trial of a Monoclonal Antibody to CD20 (Rituximab) for the Treatment of Systemic Scllerosis-Associated Pulonary Arterial Hypertension (SSc-PAH)
Robert F. Spiera, MD
12086
Prospective, Randomized, Placebo-Controlled, Double-Blind, Multicenter, Parallel group Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Patients with Ischemic Digital Ulcers Associated with Systemic Sclerosis
Robert F. Spiera, MD
12136
Phase II/III, Multicenter, Randomized, Double-blind Placebo-Controlled Study to Assess the Efficacy and Safety of Tocilizumab vs. Placebo in Patients with Systemic Sclerosis
Robert F. Spiera, MD
12006
Bellumimab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
Robert F. Spiera, MD
10115
Natural History and Outcome of Scleroderma Patients at High Risk or with Early Pulmonary Hypertension
Jessica Gordon, MD
10041
Nilotinib in the Treatment of Systemic Sclerosis
Robert F. Spiera, MD
27049
Gleevec in the Treatment of Systemic Sclerosis
Robert F. Spiera, MD
26069
Scleroderma Registry
Robert Spiera, MD
10068
DISTOL 1: Digital Ischemic Lesions in Scleroderma Treated with Oral Treprostinil Diethanolamine: a Randomized, Double-blind, Placebo-controlled, Multicenter Study
Robert F. Spiera, MD

Osteoporosis

IRB#
Clinical Trial
Principal Investigator
13214
Lower Limb Geometry in Individuals with Atypical Femoral Fractures
Joseph M. Lane, MD
12046
Retrospective Review of Education Programs for People with Musculoskeletal Disorders
Laura Robbins, DSW
27041
Fragile Bone Registry
Joseph M. Lane, MD
26033
Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures
Joseph M. Lane, MD
23017
CORRONA Data Collection Program
Allan Gibofsky, MD
10001
A Randomized, Controlled, Double-Blind Study of the Early Effects of Teriparatide versus Placebo on the Proximal Femur
Mathias P. G. Bostrom, M.D.

Vasculitis

IRB#
Clinical Trial
Principal Investigator
13114
An International, Open Label, Randomized Controlled Trial Comparing Rituximab with Azathioprine as Maintenance Therapy in Relapsing ANCA-Associated Vasculitis
Robert F. Spiera, MD
13153
Phase 3, Multi-Center, Multinational, Randomized, Double-Blind, Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006) in Combination with Azathioprine for the Maintenance of Remission in Wegener’s Granulomatosis and Microscopic Polyangiitis
Robert F. Spiera, MD
13044
Prospective, Observational Safety Study Of Patients With Granulomatosis With Polyangiitis (Wegener’s) Or Microscopic Polyangiitis Treated With Rituximab
Robert F. Spiera, MD
10159
Abatacept in Large Vessel Vasculitis
Robert Spiera, MD
25010
Rituximab Therapy For The Induction Of Remission And Tolerance In ANCA-Associated Vasculitis
Robert F. Spiera, MD
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