Clinical Trials by Condition

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Please find clinical trials at HSS listed by the following conditions:

Lupus

IRB# Clinical Trial Principal Investigator
22122 PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
23081 MINDFULL: A Randomized, Controlled Pilot Study of a Cognitive Rehabilitation Intervention Program in Systemic Lupus Erythematosus Patients Melanie J. Harrison, MD, MS
25085 Pilot and Feasibility Study of Modafinil Treatment to Improve Cognitive Efficiency in SLE Patients Melanie J. Harrison, MD, MS
26044 A Phase I, Randomized, Double-Blind, Placebo Controlled, Dose-Escalation Study To Evaluate Safety And Tolerability Of A Single IV Dose Of MEDI-545, A Fully Human Monoclonal Antibody Directed Against Interferon Alpha Subtypes Kyriakos Kirou, MD
27058 A Phase I, Randomized, Double-blind, Placebo-controlled, Escalating Single- and Multiple-dose Study of the Safety, Tolerability, and Pharmakokinetics of RhuMab IFN alpha in Adults with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
27089 A Sequential Adaptive Phase II/III Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept Versus Placebo on a Background of Mycophenolate Mofetil and Glucocorticosteroids in Subjects with Active Proliferative Glomerulonephritis Due to Systemic Lupus Erythematosus(SLE) Kyriakos A. Kirou, MD, FACR
27135 The Systemic Lupus Erythematosus (SLE) Activity Gene Expression (SAGE) Study Kyriakos A. Kirou, MD
28027 A Phase 1b Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation study with an open-label extension to evaluate the safety and tolerability of multiple IV doses of Medi-545, a fully Human Anti-interferon-alpha Monoclonal Antibody, in patients with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
28034 Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study To Evaluate The Efficacy and Safety of Two Doses of Ocrelizumab in Patients With WHO or ISN Class III or IV Nephritis Due To Systemic Lupus Erythematosus. Michael D. Lockshin, M.D.
28053 A Randomized, Double Blind, Placebo Controlled, Multicenter Prospective Dose Finding Phase II/III Study with Atacicept Given Subcutaneously to Subjects having Recently Experienced a Flare of SLE3 Michael D. Lockshin, M.D.
93029 Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
95004 Autoimmune Disease Registry and Repository Jane E. Salmon, MD

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.



Antiphospholipid Syndrome

IRB# Clinical Trial Principal Investigator
28023 Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients Doruk Erkan, MD
28005 Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome Doruk Erkan, MD
27022 RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS) Doruk Erkan, MD
22122 PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
95004 Autoimmune Disease Registry and Repository Jane E. Salmon, MD


Arthritis

IRB# Clinical Trial Principal Investigator
23017 CORRONA Data Collection Program Allan Gibofsky, MD
23108 Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis Robert G. Marx, MD
24067 Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC Lisa C. Vasanth, MD
23034 Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls Lisa A. Mandl, MD, MPH
26043 A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial Lisa A. Mandl, MD, MPH
25022 Quantitative Assessment of the Synovial Vascularity in Early Inflammatory Arthritis Lisa A. Mandl, MD, MPH
27001 Incidence and Severity of Nausea after Primary Total Hip Arthroplasty for Osteoarthritis Jacques T. YaDeau, MD, PhD


Arthroplasty

IRB# Clinical Trial Principal Investigator
26035 Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial Lisa A. Mandl, MD, MPH
29019 Effect of Limb Lengthening on Nerve Neurophysiology in Human Model Robert Rozbruch, MD
26117 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Shoulder Arthroplasty Cohort Robert Marx MD, MSc
26131 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Hip Arthroplasty Cohort Thomas P. Sculco, MD
29007 A Randomized Controlled Investigation of Postoperative Pain Following Posterior Iliac Crest Bone Graft Harvesting in Spine Surgery Russel C. Huang, MD
23017 CORRONA Data Collection Program Allan Gibofsky, MD
28098 Effect of Optimal Regional Analgesia on Arterial Tone after Total Hip Arthroplasty Nigel E. Sharrock, MD, ChB
28091 MRI Imaging of Orthopedic Instrumentation. Prospective Evaluation Utilizing Multi-Acquisition Variable-Resonance Image Combination (MAVRIC) Hollis G. Potter, MD
26079 Deep Vein Thrombosis (DVT) Prevention in Total Hip Replacement: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH) Douglas E. Padgett, MD
21137 Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength Bryan J. Nestor. MD
28053 A Randomized, Double Blind, Placebo Controlled, Multicenter Prospective Dose Finding Phase II/III Study with Atacicept Given Subcutaneously to Subjects having Recently Experienced a Flare of SLE3 Michael D. Lockshin, M.D.
28034 Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study To Evaluate The Efficacy and Safety of Two Doses of Ocrelizumab in Patients With WHO or ISN Class III or IV Nephritis Due To Systemic Lupus Erythematosus. Michael D. Lockshin, M.D.
28023 Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients Doruk Erkan, MD
28005 Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome Doruk Erkan, MD
27022 RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS) Doruk Erkan, MD
25085 Pilot and Feasibility Study of Modafinil Treatment to Improve Cognitive Efficiency in SLE Patients Melanie J. Harrison, MD, MS
25058 EXPLORER: A randomized, double-blind, placebo controlled, multicenter, phase II/III study to evaluate the efficacy and safety of rituximab in subjects with moderate to severe systemic lupus erythematosus Michael D. Lockshin, MD
27027 Vitamin D Status Among Trauma Patients; Acute Fractures/Non-unions vs. Primary Joint Arthroplasty (control population) Joseph M. Lane, MD
28117 The Effect of Intraoperative Ventilation with Low versus Traditional Tidal Volumes on Markers of Lung Injury during Spinal Surgery. Stavros G. Memtsoudis, MD
26073 Evaluation of migration of a cementless, flat, tapered femoral component using RSA Edwin P. Su, MD
24067 Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC Lisa C. Vasanth, MD
23034 Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls Lisa A. Mandl, MD, MPH
26043 A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial Lisa A. Mandl, MD, MPH
28041 The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty Stavros G. Memtsoudis, MD
27001 Incidence and Severity of Nausea after Primary Total Hip Arthroplasty for Osteoarthritis Jacques T. YaDeau, MD, PhD
26132 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Knee Arthroplasty Cohort Thomas P. Sculco, MD
22007 Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients Geoffrey Westrich, MD
21072 The Genetic Factor: Identifying Patients at High Risk for Developing Pulmonary Embolism (PE) After Orthopedic Surgery (Upper Extremity, Spine, THR, TKR) Using A Molecular Screening Test Geoffrey H. Westrich, MD


Foot and Ankle Conditions

IRB# Clinical Trial Principal Investigator
28019 Early Mobilization following Adult Acquired Flatfoot Deformity Reconstruction Jonathan T. Deland, M.D.
28021 In Vivo Radiographic Validation of Novel EMED Plantar Pressure Masking Algorithm Jonathan T. Deland, MD
26071 Development of a Geometric Foot Model: A Tool for Clinical Decision Making Howard J. Hillstrom, PhD


Knee Conditions

IRB# Clinical Trial Principal Investigator
26035 Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial Lisa A. Mandl, MD, MPH
21137 Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength Bryan J. Nestor. MD
27142 A Randomized Comparison of NeoCart® to Microfracture for the Repair of Articular Cartilage Injuries in the Knee Riley J. Williams III, MD
27127 Prospective Study of the effects of Femoral Nerve Block on Quadriceps Strength Post ACL Allograft Reconstruction Thomas L. Wickiewicz, MD
22129 Bone Tunnel Widening Following ACL (Anterior Cruciate Ligament) Reconstruction Scott Rodeo, MD
27128 Pilot Study Assessing Weight Bearing Multiplanar Imaging Compared to Supine CT and Upright Conventional Imaging of the Knee Andrew Pearle, MD
28041 The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty Stavros G. Memtsoudis, MD


Shoulder Conditions

IRB# Clinical Trial Principal Investigator
27071 Adhesive Capsulitis: A Quantitative Analysis of Myofibroblast Proliferation Jo A Hannafin, MD
27003 A Randomized Controlled Trial Evaluating the Efficacy and Complications of Interscalene Block Using the Nerve Stimulator vs. Ultrasound Approach Spencer S. Liu, MD
27020 Intraarticular Corticosteroid Injection for Idiopathic Adhesive Capsulitis of the Shoulder Jennifer L. Solomon, MD
27122 Supraclavicular vs Interscalene Brachial Plexus Block for Shoulder Surgery Christopher A DiMeo, MD
27050 The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability. Sherry I. Backus PT, DPT, MA
27012 Efficacy and Side Effect Profile of Ultrasound-guided Supraclavicular Block for Shoulder Surgery Christopher A DiMeo, MD


Spine Conditions

IRB# Clinical Trial Principal Investigator
26118 Genetic Mapping Studies of Adolescent Idiopathic Scoliosis Cathleen L. Raggio, MD
27016 Osteogenic Differentiation of Human Mesenchymal Stem Cells Wei Zhu, Ph.D.
26033 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Joseph M. Lane, MD


Skeletal Dysplasias

IRB# Clinical Trial Principal Investigator
25039 A Randomized Double Blind Placebo Controlled Multi-Center Parallel Group Study of One Year Duration Followed by Two Years of open-label Treatment to Determine the Safety and Efficacy of Orally Administered 2.5 mg or 5.0 mg Daily Risedronate Cathleen L. Raggio, MD
23125 The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry Cathleen Raggio, MD


Scleroderma

IRB# Clinical Trial Principal Investigator
26002 Scleroderma Cyclophosphamide or Transplantation (SCOT) Study Robert F. Spiera, MD
27049 Gleevec in the Treatment of Systemic Sclerosis Robert F. Spiera, MD
26069 Scleroderma Registry Robert Spiera, MD


Osteoporosis

IRB# Clinical Trial Principal Investigator
23017 CORRONA Data Collection Program Allan Gibofsky, MD
27041 Fragile Bone Registry Joseph M. Lane, MD
26033 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Joseph M. Lane, MD