Clinical Trials by Condition

 Email |  Print | Share
 

Please find clinical trials at HSS listed by the following conditions:

Lupus

IRB# Clinical Trial Principal Investigator
22122 PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
28027 A Phase 1b Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation study with an open-label extension to evaluate the safety and tolerability of multiple IV doses of Medi-545, a fully Human Anti-interferon-alpha Monoclonal Antibody, in patients with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
28053 A Randomized, Double Blind, Placebo Controlled, Multicenter Prospective Dose Finding Phase II/III Study with Atacicept Given Subcutaneously to Subjects having Recently Experienced a Flare of SLE3 Michael D. Lockshin, M.D.
29047 A Randomized, Double-Blind, Placebo-Controlled, Single Dose-Escalation And Multiple Dose Extension Trial Of NNC 0152-0000-0001 Administered I.V or S.C.. in Subjects with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
29099 A Phase II Randomized Double- Blind, Placebo- Controlled Study to Evaluate the Efficacy and Safety of Rontalizumab (rhuMAb IFNalpha) In Patients with Moderately to Severely Active SLE. Kyriakos A. Kirou, MD
93029 Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
95004 Autoimmune Disease Registry and Repository Jane E. Salmon, MD

Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus research.



Antiphospholipid Syndrome

IRB# Clinical Trial Principal Investigator
28023 Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients Doruk Erkan, MD
28005 Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome Doruk Erkan, MD
27022 RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS) Doruk Erkan, MD
22122 PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Jane E. Salmon, MD
95004 Autoimmune Disease Registry and Repository Jane E. Salmon, MD


Arthritis

IRB# Clinical Trial Principal Investigator
23017 CORRONA Data Collection Program Allan Gibofsky, MD
23108 Evaluation of Intra-articular Injuries as Predictors of Function and Arthritis Robert G. Marx, MD
24067 Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC Lisa C. Vasanth, MD
23034 Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls Lisa A. Mandl, MD, MPH
26043 A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial Lisa A. Mandl, MD, MPH
25022 Quantitative Assessment of the Synovial Vascularity in Early Inflammatory Arthritis Lisa A. Mandl, MD, MPH


Arthroplasty

IRB# Clinical Trial Principal Investigator
10015 Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study Allison M. Brown, PT, MA
29099 A Phase II Randomized Double- Blind, Placebo- Controlled Study to Evaluate the Efficacy and Safety of Rontalizumab (rhuMAb IFNalpha) In Patients with Moderately to Severely Active SLE. Kyriakos A. Kirou, MD
28098 Effect of Optimal Regional Analgesia on Arterial Tone after Total Hip Arthroplasty Nigel E. Sharrock, MD, ChB
29133 Subsartorial Saphenous Nerve Block in ACL Reconstruction Mary F. Chisholm, MD
29123 The Effects of Surface Cross-Slope on Joint Kinematics in Female Runners with Iliotibial Band Syndrome Allison M. Brown, PT, MA
26095 Pre-operative Identifiers Indicating Surgical Intervention for Wrist Deformity in Cerebral Palsy Pre-operative Identifiers Indicating Surgical Intervention for Wrist Deformity in Cerebral Palsy
28123 Removal of Volar Plates after Distal Radius Fracture Michelle G. Carlson, MD
29126 Upper Extremity and Hemispherectomy: A Case Study Michelle G Carlson, MD
29065 The Anatomy of the Collateral Ligaments of the Thumb MP Joint and Strength-Testing of a New Construction Michelle G. Carlson, MD
29048 A1 and A2 pulley release for the treatment of MCP hyperextension in Cerebral Palsy Michelle G. Carlson, MD
29108 Treatment of the Upper Extremity in Elite Athletes Michelle G. Carlson, MD
27023 Pre-operative Identifiers Indicating Surgical Intervention for Elbow Flexion Deformity in Children and Adolescents Who Have Suffered a Brain Injury at a Young Age Michelle G. Carlson, MD
29047 A Randomized, Double-Blind, Placebo-Controlled, Single Dose-Escalation And Multiple Dose Extension Trial Of NNC 0152-0000-0001 Administered I.V or S.C.. in Subjects with Systemic Lupus Erythematosus Kyriakos A. Kirou, MD
29112 Upper Extremity and Hemispherectomy: A Case Study Michelle G. Carlson, MD
26115 Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength Bryan J. Nestor. MD
29025 Lumbar Intradiscal Platelet Rich Plasma Injections: A Prospective, Double-blinded, Randomized Controlled Study Gregory E. Lutz, MD
26035 Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial Lisa A. Mandl, MD, MPH
29060 Intraoperative Fluid Management During Complex Spine Surgery Using the FloTrac System Michael K. Urban, MD
29019 Effect of Limb Lengthening on Nerve Neurophysiology in Human Model Robert Rozbruch, MD
26117 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Shoulder Arthroplasty Cohort Robert Marx MD, MSc
26131 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Hip Arthroplasty Cohort Thomas P. Sculco, MD
29007 A Randomized Controlled Investigation of Postoperative Pain Following Posterior Iliac Crest Bone Graft Harvesting in Spine Surgery Russel C. Huang, MD
23017 CORRONA Data Collection Program Allan Gibofsky, MD
28091 MRI Imaging of Orthopedic Instrumentation. Prospective Evaluation Utilizing Multi-Acquisition Variable-Resonance Image Combination (MAVRIC) Hollis G. Potter, MD
26079 Deep Vein Thrombosis (DVT) Prevention in Total Hip Replacement: Continuous Enhanced Circulation Therapy (CECT) Versus Low Molecular Weight Heparin (LMWH) Douglas E. Padgett, MD
28053 A Randomized, Double Blind, Placebo Controlled, Multicenter Prospective Dose Finding Phase II/III Study with Atacicept Given Subcutaneously to Subjects having Recently Experienced a Flare of SLE3 Michael D. Lockshin, M.D.
28023 Cognitive Dysfunction, Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging (MRI) in Antiphospholipid Antibody (aPL)-negative Systemic Lupus Erythematosus (SLE) versus aPL-positive non-SLE Patients Doruk Erkan, MD
28005 Effects of Fluvastatin on Proinflammatory and Prothrombotic markers in Antiphospholipid Syndrome Doruk Erkan, MD
27022 RITAPS: A Pilot Study Of Rituximab For The Anticoagulation-Resistant Manifestations Of Antiphospholipid Syndrome (APS) Doruk Erkan, MD
25058 EXPLORER: A randomized, double-blind, placebo controlled, multicenter, phase II/III study to evaluate the efficacy and safety of rituximab in subjects with moderate to severe systemic lupus erythematosus Michael D. Lockshin, MD
27027 Vitamin D Status Among Trauma Patients; Acute Fractures/Non-unions vs. Primary Joint Arthroplasty (control population) Joseph M. Lane, MD
28117 The Effect of Intraoperative Ventilation with Low versus Traditional Tidal Volumes on Markers of Lung Injury during Spinal Surgery. Stavros G. Memtsoudis, MD
26073 Evaluation of migration of a cementless, flat, tapered femoral component using RSA Edwin P. Su, MD
24067 Database of the Gosden Robinson Early Arthritis Center (EAC): Analysis of Types of Patients Recruited to an Urban EAC Lisa C. Vasanth, MD
23034 Open Label Trial for Treating Carpometacarpal Osteoarthritis: PILOT STUDY - Sub-study on Normal Controls Lisa A. Mandl, MD, MPH
26043 A Study of Hyaluronan (Synvisc) for the Treatment of Osteoarthritis in the Thumb: Randomized Control Trial Lisa A. Mandl, MD, MPH
28041 The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty Stavros G. Memtsoudis, MD
26132 Prospective Evaluation of the Clinical and Economic Outcomes of Total Joint Replacement: The HSS Knee Arthroplasty Cohort Thomas P. Sculco, MD
22007 Hyalgan Treatment of Osteoarthritis in Post-Operative Knee Arthroplasty Patients Geoffrey Westrich, MD
21072 The Genetic Factor: Identifying Patients at High Risk for Developing Pulmonary Embolism (PE) After Orthopedic Surgery (Upper Extremity, Spine, THR, TKR) Using A Molecular Screening Test Geoffrey H. Westrich, MD


Foot and Ankle Conditions

IRB# Clinical Trial Principal Investigator
10015 Understanding the Effects of the “Ankle Sprain Reducing Shoe” on Ankle Joint Kinetics, Kinematics, Electromyography, and Neuromuscular Balance Control: A Pilot Study Allison M. Brown, PT, MA
28019 Early Mobilization following Adult Acquired Flatfoot Deformity Reconstruction Jonathan T. Deland, M.D.
28021 In Vivo Radiographic Validation of Novel EMED Plantar Pressure Masking Algorithm Jonathan T. Deland, MD
26071 Development of a Geometric Foot Model: A Tool for Clinical Decision Making Howard J. Hillstrom, PhD


Knee Conditions

IRB# Clinical Trial Principal Investigator
26035 Arthroscopic Partial Meniscectomy in Osteoarthritis: A Randomized Control Trial Lisa A. Mandl, MD, MPH
26115 Minimally Invasive Surgical Approach versus Standard Total Knee Arthroplasty: A Prospective Randomized Double Blinded Study Comparing Postoperative Strength Bryan J. Nestor. MD
27142 A Randomized Comparison of NeoCart® to Microfracture for the Repair of Articular Cartilage Injuries in the Knee Riley J. Williams III, MD
27127 Prospective Study of the effects of Femoral Nerve Block on Quadriceps Strength Post ACL Allograft Reconstruction Thomas L. Wickiewicz, MD
22129 Bone Tunnel Widening Following ACL (Anterior Cruciate Ligament) Reconstruction Scott Rodeo, MD
28041 The Effect of Ischemic Preconditioning on Systemic Inflammatory Markers after Total Knee Arthroplasty Stavros G. Memtsoudis, MD


Shoulder Conditions

IRB# Clinical Trial Principal Investigator
27071 Adhesive Capsulitis: A Quantitative Analysis of Myofibroblast Proliferation Jo A Hannafin, MD
27020 Intraarticular Corticosteroid Injection for Idiopathic Adhesive Capsulitis of the Shoulder Jennifer L. Solomon, MD
27122 Supraclavicular vs Interscalene Brachial Plexus Block for Shoulder Surgery Christopher A DiMeo, MD
27050 The Effect of McConnell Shoulder Taping on EMG Activity and Torque Production of the Shoulder Muscles in Subjects With Anterior Shoulder Instability. Sherry I. Backus PT, DPT, MA


Spine Conditions

IRB# Clinical Trial Principal Investigator
26118 Genetic Mapping Studies of Adolescent Idiopathic Scoliosis Cathleen L. Raggio, MD
27016 Osteogenic Differentiation of Human Mesenchymal Stem Cells Wei Zhu, Ph.D.
26033 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Joseph M. Lane, MD


Skeletal Dysplasias

IRB# Clinical Trial Principal Investigator
25039 A Randomized Double Blind Placebo Controlled Multi-Center Parallel Group Study of One Year Duration Followed by Two Years of open-label Treatment to Determine the Safety and Efficacy of Orally Administered 2.5 mg or 5.0 mg Daily Risedronate Cathleen L. Raggio, MD
23125 The Kathryn O. and Alan C. Greenberg Center for Skeletal Dysplasias Clinical Research Registry Cathleen Raggio, MD


Scleroderma

IRB# Clinical Trial Principal Investigator
27049 Gleevec in the Treatment of Systemic Sclerosis Robert F. Spiera, MD
26069 Scleroderma Registry Robert Spiera, MD
26002 Scleroderma Cyclophosphamide or Transplantation (SCOT) Study Robert F. Spiera, MD


Osteoporosis

IRB# Clinical Trial Principal Investigator
23017 CORRONA Data Collection Program Allan Gibofsky, MD
27041 Fragile Bone Registry Joseph M. Lane, MD
26033 Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures Joseph M. Lane, MD