Rheumatology Clinical Research Center (RCRC): Recent Publications

Rheumatology

Doruk Erkan, MD
Allan Gibofsky, MD, JD
Michael D. Lockshin, MD
Lisa Mandl, MD, MPH

Doruk Erkan, MD

Selected Journal Articles (Antiphospholipid Syndrome):

Erkan D, Bateman H, Lockshin MD. Lupus-anticoagulant - Hypoprothrombinemia syndrome associated with systemic lupus erythematosus: report of 2 cases and review of literature. Lupus 1999;8(7):560-564.

Erkan D, Yazici Y, Sobel R, Lockshin MD. Primary Antiphospholipid Syndrome. Functional outcome after 10 years. Journal of Rheumatology 2000;27:2817-2821.

Erkan D, Merrill JT, Yazici Y, Sammaritano L, Buyon JP, Lockshin MD. High thrombosis rate after fetal loss in antiphospholipid syndrome – Effective prophylaxis with aspirin. Arthritis & Rheumatism 2001;44(6):1466-1467.

Erkan D, Leibowitz E, Berman J, Lockshin MD. Perioperative medical management of antiphospholipid syndrome: Hospital for Special Surgery experience, review of the literature and recommendations. Journal of Rheumatology 2002;29(4):843-849.

Erkan D, Zhang HW, Shriky RC, Merrill JT. Dual Antibody Reactivity to Beta-2 Glycoprotein-1 and Protein S: Increased association with thrombotic events in antiphospholipid syndrome. Lupus 2002;11(4):215-220.

Erel H, Erkan D, Lehman TJ, Prince MR. Diagnostic usefulness of 3 dimensional gadolinium enhanced magnetic resonance venography in antiphospholipid syndrome. Journal of Rheumatology 2002;29(6):1338-1339.

Burcoglu-O’ral A, Erkan D, Asherson RA. Treatment of Catastrophic Antiphospholipid Syndrome (CAPS) with Defibrotide - A Proposed Vascular Endothelial Cell Modulator. Journal of Rheumatology 2002;29(9):2006-2011.

Erkan D. The Relation Between Antiphospholipid Syndrome-Related Pregnancy Morbidity and Non-gravid Vascular Thrombosis: Review of the Literature and Management Strategies. Current Rheumatology Reports 2002;4(5):379-386.

Erkan D, Yazici Y, Peterson M, Sammaritano L, Lockshin MD. A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology 2002;41:924-929.

Erkan D, Erel H, Yazici Y, Prince MR. The role of cardiac magnetic resonance imaging in antiphospholipid syndrome. Journal of Rheumatology 2002;29(12):2658-2659.

Erkan D, Lockshin MD. Antiphospholipid Syndrome. Bulletin on the Rheumatic Diseases 2003;52(3):1-4.

Erkan D, Asherson RA, Espinosa G, Cervera R, Font J, Piette JC, Lockshin MD. The long-term outcome of catastrophic antiphospholipid syndrome survivors. Annals of Rheumatic Diseases 2003;62:530-533.

Asherson RA, Cervera R, de Groot P, Erkan D, Boffa MC, Piette JC, Khamashta MA, Shoenfeld Y. Catastrophic Antiphospholipid Syndrome (CAPS): International Consensus Statement on Classification Criteria and Treatment Guidelines. Lupus 2003;12(7):530-534.

Lockshin MD, Tenedios F, Petri M, McCarty G, Forastiero R, Krilis S, Tincani A, Erkan D, Khamashta MA Shoenfeld Y. Cardiac disease in antiphospholipid syndrome: Recommendations for treatment. Committee consensus report. Lupus 2003;12(7):518-523.

Lockshin MD, Erkan D. Treatment of the Antiphospholipid Syndrome (editorial). New England Journal of Medicine 2003;349;12:1177-1179.

Erkan D, Sammaritano L. New Insights into pregnancy-related complications in systemic lupus erythematosus. Current Rheumatology Reports 2003;5(5):357-363.

Erkan D, Cervera R, Asherson RA. Catastrophic Antiphospholipid Syndrome: Where do we stand? (review). Arthritis & Rheumatism 2003;48(12):3320-3327.

Erkan D, Lockshin MD. How much warfarin is enough in Antiphospholipid Syndrome-related thrombosis? Thrombosis Research 2004;114(5-6):435-442.

Erkan D, Lockshin MD. What is Antiphosholipid Syndrome? Current Rheumatology Reports 2004;6(6):451-457.

Bermas B, Erkan D, Schur PH. Clinical manifestations and diagnosis of Antiphospholipid Syndrome. UpTodate Rheumatology & Hematology Sections 2004-2006.

Erkan D, Ortel T, Lockshin MD. Warfarin in the Antiphospholipid Syndrome – Time to explore new horizons (editorial). Journal of Rheumatology 2005;32(2):208-212.

Erkan D, Derksen W, Kaplan V, Sammaritano L, Pierangeli SS, Roubey R, Lockshin MD. Real world experience with antiphospholipid antibodies (aPL). How stable and significant are aPL? Annals of Rheumatic Diseases 2005;64(9):1321-1325. Epub 2005 Feb 24.

Tenedios F, Erkan D, Lockshin MD. Cardiac involvement in Antiphospholipid Syndrome. Lupus 2005;14(9):691-696.

Erkan D, Lockshin MD. New Treatments for Antiphospholipid Syndrome. Rheumatic Disease Clinics of North America 2006;32:129-148.

Erkan D, Lockshin MD. Antiphospholipid Syndrome. Current Opinion in Rheumatology 2006;18(3):242-248.

Vero S, Asherson RA, Erkan D. Critical Care Review: Catastrophic Antiphospholipid Syndrome. Journal of Intensive Care Medicine 2006;21:144-159.
Bucciarelli S, Espinosa G, Cervera R, Erkan D, Ramos-Casals M, Font J, Asherson RA. Mortality in the Catastrophic Antiphospholipid Syndrome: Prognostic Factors in a Series of 250 Patients. Arthritis & Rheumatism 2006;54(8):2568-2576.

Tenedios F, Erkan D, Lockshin MD. Cardiac manifestations in the Antiphospholipid Syndrome. Rheumatic Disease Clinics of North America 2006;32(3):491-507.

Erkan D. Update on Antiphospholipid Syndrome. New Developments in Rheumatic Diseases (a CME Journal for Healthcare Professionals) 2006;4(2):11-17.

Erkan D. Therapeutic and Prognostic considerations in Catastrophic Antiphospholipid Syndrome. Autoimmunity Reviews 2006 Dec;6(2):98-103. Epub 2006 Jul 21.

Erkan D. Lupus and Thrombosis. Journal of Rheumatology (editorial) 2006;33(9):1715-1717.

Bayraktar D, Erkan D, Bucciarelli S, Gerard R, Asherson RA. The clinical spectrum of catastrophic antiphospholipid syndrome in the absence of presence of lupus. Journal of Rheumatology 2007;34:346-352.

Kaul M, Erkan D, Sammaritano L, Lockshin MD. Assessment of the 2006 Revised Antiphospholipid Syndrome (APS) Classification Criteria. Annals of Rheumatic Disease 2007;66(7);927-930.

Erkan D, Harrison MJ, Levy R, Peterson M, Petri M, Sammaritano L, Unalp-Arida A, Vilela V, Yazici Y, Lockshin MD. Aspirin for Primary Thrombosis Prevention in Antiphospholipid Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial in Asymptomatic Antiphospholipid Antibody Positive Individuals. Arthritis & Rheumatism 2007;56(7):2382-2391.

George D, Vasanth L, Erkan D, Bass A, Salmon J, Lockshin MD. Primary Antiphospholipid Syndrome presenting as HELLP Syndrome - Clinical Pathology Conference. Hospital for Special Surgery Journal 2007;3(2):216-221.

Alpert D, Mandl LA, Erkan D, Yin W, Peersche EI, Salmon JE. Anti-Heparin Platelet Factor 4 Antibodies in Systemic Lupus Erythematosus are Associated with IgM Antiphospholipid Antibodies and the Antiphospholipid Syndrome. Ann Rheum Disease 2008;67(3):395-401. Epub 2007 July 20.

Erkan D, Patel S, Nuzzo M, Gerosa M, Tincani A, Meroni PL, Locksin MD. Management of Controversial Aspects of Antiphospholipid Syndrome: A Guide to Clinicians and Researchers. Rheumatology 2008;47(supp3): iii23-27.

Asherson RA, Cervera R, Merril JT, Erkan D. Antiphospholipid Antibodies and the Antiphospholipid Syndrome: Clinical Significance and Treatment. Seminars in Thrombosis and Hemostasis 2008;34(3):256-266.

Selected Journal Articles (Other Topics):

Erkan D, Merrill JT. Severe Guillain-Barre like peripheral neuropathy in a patient with systemic lupus erythematosus: recovery after two accidental burn injuries. The Journal of Clinical Rheumatology 2000;6:278-282.

Erkan D, Lam AL, Yazici Y, Magid SK. A case of VATER association mimicking spondylarthropathy. Clinical and Experimental Rheumatology 2000;18(5):651.

Erkan D, Yazici Y, Paget SA. Fever and arthritis: Narrowing the diagnosis. The Journal of Musculoskeletal Medicine 2000;17(11):676-687.

Yazici Y, Erkan D, Lockshin MD. Etanercept in the treatment of severe, resistant psoriatic arthritis. Clinical and Experimental Rheumatology 2000;18(6):732-734.

Yazici Y, Erkan D, Scott R, Paget SA. The skin: A map to rheumatic diseases. The Journal of Musculoskeletal Medicine 2001;18(1):43-53.

Erkan D, Lam AL, Yazici Y, Magid SK. VATER Association: Is it recognized by rheumatologists? Clinical Rheumatology 2001;20(2):128-131.

Yazici Y, Erkan D, Peterson MGE, Kagen LJ. Morning stiffness: How common is it and does it correlate with physician and patient global assessment of disease activity? Journal of Rheumatology 2001;28(6):1468.

Yazici Y, Erkan D, Harrison MJ, Peterson MG, Yazici H. Reporting consistency in systemic lupus erythematosus patients: How reliable are patient histories? Lupus 2002;11(1):46-48.

Yazici Y, Erkan D, Lockshin MD. Etanercept in the treatment of severe, resistant psoriatic arthritis. Continuing efficacy and changing patterns of use after 2 years. Clinical and Experimental Rheumatology 2002;20(1):115.

Yazici Y, Erkan D, Levine DM, Parker TS, Lockshin MD. Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of the literature. Lupus 2002;11(2):119-123.

Erkan D, Yazici Y, Harrison MJ, Paget SA. Physician treatment preferences in rheumatoid arthritis of differing disease severity and activity: The impact of cost on first line therapy. Arthritis Care & Research 2002;47(3):285-290.

Yazici Y, Erkan D, Kulman I, Belostocki KB, Harrison MJ. Decreased flares of rheumatoid arthritis during the first year of etanercept treatment: further evidence of clinical effectiveness in the "real world". Annals of Rheumatic Diseases 2002;61:638-640.

Erkan D, Yazici Y, Harrison MJ, Paget SA. The impact of pharmocoeconomics on the treatment of rheumatoid arthritis. Drug Benefit Trends 2002;14(SuppB):32-38.

Yazici Y, Erkan D, Paget SA. Editorial: Monitoring for methotrexate hepatic toxicity in rheumatoid arthritis patients: Is it time to update the guidelines? The Journal of Rheumatology 2002;29(8):1586-1589.

Yazici Y, Erkan D, Paget SA. Inflammatory musculoskeletal disorders in the elderly: Part I – The Journal of Musculoskeletal Medicine 2002;19(7):265-276.

Erkan D, Yazici Y, Paget SA. Inflammatory musculoskeletal disorders in the elderly: Part II – The Journal of Musculoskeletal Medicine 2002;19(8):320-329.

Yazici Y, Erkan D, Harrison MJ. Reply to the "letter to the editor" by Smith MD on "Decreased flares of rheumatoid arthritis during the first year of etanercept treatment: further evidence of clinical effectiveness in the real world". Annals of Rheumatic Diseases 2003;62(1):96.

Yazici Y, Erkan D, Zuniga R, Bateman H, Salvati EA, Magid SK. Pregnancy outcomes following total hip arthroplasty: A preliminary study and review of the literature. Orthopedics 2003;26(1):75-76.

Erkan D, Yazici Y, Paget SA. The impact of pharmocoeconomics on the treatment of rheumatoid arthritis. A 3-year longitudinal study. Drug Benefit Trends 2003;15(SuppC):8-13.

Yazici Y, Erkan D, Paget SA. Monitoring by rheumatologists for methotrexate-, etanercept-, infliximab-, and anakinra-associated adverse events. Arthritis & Rheumatism 2003;48(10):2769-2772.

Merrill JT, Erkan D, Buyon JP. Challenges in bringing the bench to bedside in drug development for systemic lupus erythematosus. Nature Reviews Drug Discovery 2004;3:1036-1046.

Erkan D. Questions & Answers. Differentiating between lupus and preeclampsia in pregnancy. Journal of Musculoskeletal Medicine 2004;21(11):568.

Erkan D, Yazici Y, Trost D, Sanders A, Yazici H. Is Hughes Stovin Syndrome Behcet's Disease? Clinical and Experimental Rheumatology 2004;22(Suppl.34):S64-68.

Yazici Y, Erkan D, Nesher G, Kural E, Seyahi N, Ince A. Behcet’s Disease: Does lack of knowledge result in underdiagnosis. Clinical and Experimental Rheumatology 2004;22(Suppl.34):S81-82.

Erkan D, Paget SA. The musculoskeletal roads less traveled (editorial). Current Opinion in Rheumatology, 2005;17:62-63.

Yazici Y, Erkan D, Harrison M, Paget SA. Methotrexate use in rheumatoid arthritis is associated with few clinically significant liver function test abnormalities. Clinical and Experimental Rheumatology 2005;23(4):517-520.

Alpert D, Davis A, Erkan D, Roman MJ, Salmon JE. The development of subclinical carotid atherosclerosis in a patient with systemic lupus erythematosus. Nature Clinical Practice Rheumatology 2007;3:473-478.

Books (Editor):

Erkan D, Levine SR. Handbook of Systemic Autoimmune Diseases, Volume 3: Neurologic Involvement in Systemic Autoimmune Diseases. Elsevier Science, Amsterdam 2004.

Associate Editor, Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, 5th Edition. Eds: Paget SA, Gibofsky A, Beary JF, Sculco T. Lippincott Williams & Wilkins, Philadelphia 2006.

Book Chapters:

Erkan D, Sammaritano L, Lockshin MD. Management of the difficult aspects of antiphospholipid syndrome. In: Antiphospholipid Syndrome II. Eds: Asherson RA, Cervera R, Piette JC, Shoenfeld Y. Elsevier Science, 2002; p:353-365.

Berman J, Erkan D, Lockshin MD. Patient’s guide to Antiphospholipid Syndrome. In: Antiphospholipid Syndrome II. Eds: Asherson RA, Cervera R, Piette JC, Shoenfeld Y. Elsevier Science, 2002; p:395-402.

Erkan D, Roman MJ, Tenedios F, Lockshin MD. Cardiac Involvement in the Antiphospholipid Syndrome. In: Handbook of Systemic Autoimmune Diseases, Volume 1: The Heart in Systemic Autoimmune Diseases. Ed: Doria A and Pauletto P. Elsevier Science, Amsterdam 2004; p:213-225..

Erkan D, Paget SA, Newton HB. Rheumatoid arthritis – Neurologic complications. In: 5-Minute Neurology Consult. Eds: Lynn DJ, Newton HB, Rae-Grant AD. Lippincott Williams & Wilkins, Philadelpia 2004; p:368-369.

Erkan D, Levine SR. Neurologic Involvement in the Antiphospholipid Syndrome. In: Handbook of Systemic Autoimmune Diseases, Volume 3: Neurologic Involvement in Systemic Autoimmune Diseases. Ed: Erkan D and Levine SR. Elsevier Science, Amsterdam, 2004; p:71-85.

Erkan D, Lockshin MD. Antiphospholipid Syndrome. In: American College of Physicians: Expert Guide to Rheumatology. Eds: Paget SA, Yee AMF. American College of Physicians, Versa Press, USA, 2004; p:95-108

Erkan D, Yazici Y. Fever and Arthritis. In: American College of Physicians: Expert Guide to Rheumatology. Eds: Paget SA, Yee AMF. American College of Physicians, Versa Press, USA, 2004; p:363-372.

Erkan D, Sammaritano LR. Antiphospholipid Syndrome. Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, 5th Edition. Eds: Paget SA, Gibofsky A, Beary JF, Sculco T. Lippincott Williams & Wilkins, Philadelphia 2006; p: 238-245.

Erkan D, Sammaritano LR. Pregnancy and Connective Tissue Disorders. Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, 5th Edition. Eds: Paget SA, Gibofsky A, Beary JF, Sculco T. Lippincott Williams & Wilkins, Philadelphia 2006; p: 297-306.

Erkan D. Lockshin MD. Antiphospholipid Syndrome. In: Clinical Immunology: Principles and Practice, 3rd Edition. Eds. Rich RR et al. Mosby Elsevier, Philadelphia 2008; p: 909-917.

Erkan D, Salmon J, Lockshin MD. Antiphospholipid Syndrome. In: Kelley’s Textbook of Rheumatology, 8th Edition. Eds: Ruddy S, Harris ED, Jr., Sledge C. Elsevier Saunders, Philadelphia 2008; p:1301-1310.

Lockshin MD, Salmon J, Erkan D. Pregnancy and Rheumatic Disease. In: Creasy and Resnik’s Maternal-Fetal Medicine, 6th Edition. Eds: Creasy RK, Resnik RR, Iams JD, Lockwood CJ, Moore TR. Elsevier, Philadelphia 2008; p1079-1088.

Allan Gibofsky, MD, JD

Selected Journal Articles:

Gibofsky A. Clinical profiles of celecoxib and rofecoxib in the rheumatic diseases. J Hypertens 2002;20:s25-s30.

Gibofsky A, Williams GW, McKenna F, Fort JG: Comparing the efficacy of cyclooxygenase 2-specific inhibitors in treating osteoarthritis: Appropriate trial design considerations and results of a randomized, placebo-controlled trial. Arthritis Rheum 2003;48:3102-3111.

Pincus T, Koch G, Lei H, Mangal B, Sokka T, Moskowitz R, Wolfe F, Gibofsky A, Simon L, Fort J. Patient preference for Placebo, Acetaminophen or Celecoxib Efficacy Studies (PACES): Two randomized placebeo-controlled cross-over clinical trials in patients with osteoarthritis of the knee or hip. Ann Rheum Dis 2004

Markenson J, Palmer WR, Gibofsky A, Garjian PA, Howland J, Xia HA, Louie JS: Real-world safety of biologics and traditional DMARDs: observations from the RADIUS registry. J Rheum 2005.

Gibofsky A: Combination therapy for Rheumatoid Arthritis in the age of Biologicals. In press J Hosp Spec Surg 2006.

Weaver AL, Lautzenheiser RL, Schiff MH, Gibofsky A, Perruquet JL, Luetkemeyer J, Paulus H, Xia HA, Leff J: Real-world effectiveness of biologics and DMARDs in the treatment of rheumatoid arthritis: results from the RADIUS observational registry. Curr Med Research Opinion 22:185-198.2006

Gibofsky A, Zabriskie JB: Rheumatic fever. In: Manual of Rheumatology and Outpatient Orthopedic Disorders, 5th edition. Edited by Paget SA , Gibofsky A, and Beary J. Lippincott Williams & Wilkins. 2005

Kyriakos K, Gibofsky A: Enteropathic arthritis. In: Manual of Rheumatology and Outpatient Orthopedic Disorders, 5th Edition. Edited by Paget SA , Gibofsky A, and Beary J. Lippincott Williams & Wilkins. 2005.

Gibofsky A, Palmer WR, Goldman JA, Lautzenheiser RL, Markenson J, Weaver AL, Schiff MH, Keystone EC, Paulus HE, Harrison MJ, Whitmore JB, Leff JA: Rheumatoid arthritis disease-modifying anti-rheumatic drug intervention and utilization Study (RADIUS): real-world data in the management of rheumatoid arthritis. Curr Med Research Opinion 22: 169-184, 2006

Gibofsky A: An Analysis of Recent Antitrust Issues Affecting Specialty Practice: Is Dermatology Immune? Seminars Cut Med & Surg 24: 137-143. 2005.

Selected Book Chapters:

Kyriakos K, Gibofsky A: Enteropathic arthritis. In: Manual of Rheumatology and Outpatient Orthopedic Disorders, 4th Edition. Edited by Paget SA , Gibofsky A, and Beary J. Lippincott Williams & Wilkins. 2000.

Gibofsky A, Zabriskie JB: Rheumatic fever. In: Manual of Rheumatology and Outpatient Orthopedic Disorders, 4th edition. Edited by Paget SA , Gibofsky A, and Beary J. Lippincott Williams & Wilkins. 2000

Yazici Y, Gibofsky A: Rheumatic fever, Sjogrens syndrome and relapsing polychondritis. In: Clinical Primer of Rheumatology. Edited by Koopman WJ, Boulware D and Heudebert, GR. Lippincott Williams & Wilkins.2003

Michael D. Lockshin, MD

Selected Journal Articles:

Erkan D, Merrill JT, Yazici Y, Sammaritano L, Buyon JP, Lockshin MD. High thrombosis rate after fetal loss in antiphospholipid syndrome: effective prophylaxis with aspirin.Arthritis Rheum. 2001 Jun;44(6):1466-7.

Lockshin MD. Invited review: sex ratio and rheumatic disease.J Appl Physiol. 2001 Nov;91(5):2366-73.

Lockshin MD, Salmon JE, Roman MJ. Atherosclerosis and lupus: a work in progress. Arthritis Rheum. 2001 Oct;44(10):2215-7.

Lockshin MD. Sex ratio and rheumatic disease. Isr Med Assoc J. 2001 Jul;3(7):511-6.

Yazici Y, Erkan D, Lockshin MD. Etanercept in the treatment of severe, resistant psoriatic arthritis: continued efficacy and changing patterns of use after two years. Clin Exp Rheumatol. 2002 Jan-Feb;20(1):115.

Erkan D, Leibowitz E, Berman J, Lockshin MD. Perioperative medical management of antiphospholipid syndrome: hospital for special surgery experience, review of literature, and recommendations. J Rheumatol. 2002 Apr;29(4):843-9.

Yazici Y, Erkan D, Levine DM, Parker TS, Lockshin MD. Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology. Lupus. 2002;11(2):119-23.

Lockshin MD. Endocrine origins of rheumatic disease. Diagnostic clues to interrelated syndromes. Postgrad Med. 2002 Apr;111(4):87-8, 91-2.

Erkan D, Yazici Y, Peterson MG, Sammaritano L, Lockshin MD. A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology (Oxford). 2002 Aug;41(8):924-9.

Lockshin MD. Sex ratio and rheumatic disease: excerpts from an Institute of Medicine report. Lupus. 2002;11(10):662-6.

Ross G, Sammaritano L, Nass R, Lockshin MD. Effects of mothers' autoimmune disease during pregnancy on learning disabilities and hand preference in their children. Arch Pediatr Adolesc Med. 2003 Apr;157(4):397-402.

Erkan D, Asherson RA, Espinosa G, Cervera R, Font J, Piette JC, Lockshin MD. Catastrophic Antiphospholipid Syndrome Registry Project Group. Long-term outcome of catastrophic antiphospholipid syndrome survivors. Ann Rheum Dis. 2003 Jun;62(6):530-3.

Lockshin MD, Sammaritano LR. Lupus pregnancy. Autoimmunity. 2003 Feb;36(1):33-40.

Lockshin MD. Sex ratio and rheumatic disease. Autoimmun Rev. 2002 May;1(3):162-7.

Lockshin MD, Tenedios F, Petri M, McCarty G, Forastiero R, Krilis S, Tincani A, Erkan D,

Khamashta MA, Shoenfeld Y. Cardiac disease in the antiphospholipid syndrome: recommendations for treatment. Committee consensus report. Lupus. 2003;12(7):518-23.
Lockshin MD, Erkan D. Treatment of the antiphospholipid syndrome.N Engl J Med. 2003 Sep 18;349(12):1177-9.

Roman MJ, Shanker BA, Davis A, Lockshin MD, Sammaritano L, Simantov R, Crow
MK, Schwartz JE, Paget SA, Devereux RB, Salmon JE. Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus. N Engl J Med. 2003 Dec 18;349(25):2399-406.

Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin MD, Looi LM, Makino H, Moura LA, Nagata M; International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int. 2004 Feb;65(2):521-30.

Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijn JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennette JC, Kong NC, Lesavre P, Lockshin MD, Looi LM, Makino H, Moura LA, Nagata M. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol. 2004 Feb;15(2):241-50.

Ruiz-Irastorza G, Khamashta MA, Gordon C, Lockshin MD, Johns KR, Sammaritano L, Hughes GR. Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale. Arthritis Rheum. 2004 Feb 15;51(1):78-82.

Derksen WJ, Erkan D, Potter HG, Lockshin MD. Interferon induced digital artery vasculitis. J Rheum 2005; 32:191-2.

Erkan D, Lockshin MD. What is Antiphosholipid Syndrome? Curr Rheumatol Rep 2004;6:451-457.

Erkan D, Ortel T, Lockshin M. Warfarin in the Antiphospholipid Syndrome – Time to explore new horizons. J Rheum 2005;32:208-212.

Buyon JP, Petri MA; Kim MY, Kalunian K, Grossman J, Hahn BH, Merrill JT, Sammaritano L, Lockshin M, Alarcon G, Manzi S, Belmont HM, Askanase AD, Sigler L, Dooley MA, Von Feldt J, McCune WJ, Alan Friedman F, Wachs J, Cronin M, Hearth-Holmes M, Tan M, MD Licciardi F, for the SELENA Investigators. Estrogen/cyclic progesterone replacement is associated with an increased rate of mild/moderate but not severe flares in SLE. Ann Intern Med 2005; 142:953-962.

Roman MJ, Devereux RB, Schwartz JE, Lockshin MD, Paget SA, Davis A, Crow MK, Sammaritano L, Levine DM, Shankar BA, Elfi Moeller E, Salmon JE. Arterial stiffness in chronic inflammatory diseases. Hypertension. 2005;46:1-6.

Tenedios F, Erkan D, Lockshin MD. Cardiac involvement in the antiphospholipid syndrome. Lupus 2005; 14: 691-6.

Stone JH, Lockshin MD, Katz PP, Yelin EH. New journal policy regarding registration of clinical trials. Arthritis Rheum. 2005 Aug;52(8):2243-7.

Lockshin MD. Standing and new policies and procedures for Arthritis & Rheumatism. Arthritis Rheum 2005;52: 3683-4.

Erkan D, Derksen WJM, Kaplan V, Sammaritano L, Pierangeli SS, Roubey R, Lockshin MD. Real world experience with antiphospholipid antibody tests: how stable are results over time? Ann Rheum Dis 2005; e-pub 31856 June 28 2005

Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, Lockshin M, Merrill JT, Belmont HM, Askanase AC, McCune WJ, Hearth-Holmes M, Dooley MA, Von Feldt J, Friedman A, Tan M, Davis J, Cronin M, Diamond B, Mackay M, Sigler L, Fillius M, Rupel A, Licciardi F, Buyon JP. Combined oral contraceptives in women with systemic lupus erythematosus. New Engl J Med 2005;353:2550-8.

Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RHWM, de Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Ttincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thrombosis Haemostasis 2006; 4:295-306.

Erkan D, Lockshin MD. New Treatments for Antiphospholipid Syndrome Rheum Dis Clin N Am 2006; 32: 129–148

Erkan D, Lockshin MD. Antiphospholipid Syndrome. Current Opinion in Rheumatology 2006;18(3):242-248.

Erkan D, Harrison MJ, Levy R, Peterson M, Petri M, Sammaritano L, Vilela V, Yazici Y, Lockshin MD. A Randomized Double-blind Placebo-controlled Primary Thrombosis Prevention Trial in Asymptomatic Persistently Antiphospholipid Antibody Positive Individuals with Aspirin. Arthritis Rheum 2007;56: 2382-2391

Zhang L, Harrison M, Heier LA, Zimmerman RD, Ravdin L, Lockshin M, Ulug AM. Diffusion changes in patients with systemic lupus erythematosus. Magnetic Resonance Imaging 2007; 25: 399–405

Lockshin MD, The Mary Kirkland Center for Lupus Research Consortium. Biology of the sex and age distribution of systemic lupus erythematosus. Arthritis Rheum. 2007 May 15;57(4):608-11.

Lockshin MD, Buyon JP. Estrogens and lupus: bubbling cauldron or another overrated Witches' Brew? Arthritis Rheum. 2007 Apr;56(4):1048-50 (editorial).

Pieretti J, Roman MJ, Devereux RB, Lockshin MD, Crow MK, Paget SA, Schwartz JE, Sammaritano L, Levine DM, SalmonJE. Systemic lupus erythematosus increases left ventricular mass independent of traditional dtimuli to hypertrophy, Circulation 2007 Jul 24;116(4):419-26. Epub 2007 Jul 9.

Ad Hoc Committee on Lupus Response Criteria: Cognition Sub-committee (Mikdashi J, Esdaile JM, Alarcon GS, Crofford L, Fessler BJ, Shanberg L, Brunner H, Gail V, Kalden JR, Lockshin MD, Liang MH, Roberts N, Jr., Schneider M.). Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials. Lupus 2007;16:418-425.

George D, Vasanth L, Erkan D, Bass A, Salmon J, Lockshin MD. Primary antiphospholipid syndrome presenting as HELLP syndrome: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery. HSS Journal 2007;2:216-221.

Rudominer RL, Roman MJ, Devereux RB, Paget SA, Schwartz JE, Lockshin MD, Crow MK, Sammaritano L, Levine DM, Salmon JE. Independent association of rheumatoid arthritis with increased left ventricular mass but not with reduced ejection fraction. Arthritis Rheum. 2008 Dec 30;60(1):22-29

Selected Book Chapters

Yazici Y, Lockshin MD, Vasculitis, in Manual of Rheumatology and Orthopedics, Paget S, Pellicci P, Gibofsky A, Beary J, editors, Philadelphia:Lippincott-Raven, 2000, pp. 258-268

Lockshin MD, Endocrine arthropathies, in Manual of Rheumatology and Orthopedics, Paget S, Pellicci P, Gibofsky A, Beary J, editors, Philadelphia:Lippincott-Raven, 2000, pp. 362-364

Masi AT, Feigenbaum SL, Lockshin MD. Clinical Maternal-Fetal Medicine, Winn HN, Hobbins JC, eds., London:Parthenon, 2000, pp. 515-533.

Lockshin MD, Antiphospholipid syndrome, in Kelley’s Textbook of Rheumatology, Ruddy S, Harris ED, Jr., Sledge C, editors, Philadelphia:W B Saunders, 6th Edition, 2001, pp 1145-52

Lockshin MD. Prognosis and future directions. In: Hughes GRV, Khamashta M, eds. Hughes Syndrome. London:Springer-Verlag, 2000, pp. 459-462.

Lockshin MD, Sammaritano LR: Rheumatic disease. Medical Disorders During Pregnancy (Third Edition), Barron WM, Lindheimer MD, eds. St. Louis: Mosby Year Book, 2000, pp 355-391.

Lockshin MD. Pregnancy and rheumatic diseases, in Arthritis and Allied Conditions 14th Edition), Koopman WJ, editor, Baltimore:Lippincott Williams & Wilkins, 2001, pp. 1799-1808

Lockshin MD. Systemic lupus erythematosus and pregnancy. The Female Patient 2000;25:89-93

Wizemann T, Pardue ML, editors, Exploring the Biological Contributions to Human Health: Does Sex Matter? Institute of Medicine Report, Washington:National Academy Press, 2001 (Committee member)

Sammaritano LR, Lockshin MD. SLE in pregnancy, in Rheumatology and the Kidney, Adu D, Emery P, Madaio MP, editors, Oxford:Oxford, 2001

Lockshin MD, Systemic Lupus Erythematosus, in Gotto A (ed.): DISEASEDEX(tm) - General Medicine, posted November 20, 2002. MICROMEDEX, Greenwood Village, Colorado http://www.mdx.com/products/diseasedexgeneral/

Berman J, Erkan D, Lockshin MD. A patient’s guide to the antiphospholipid syndrome, in The Antiphospholipid Syndrome, Asherson RA, Cervera R, Piette J-C, Shoenfeld Y, editors, Elsevier Science BV, 2002, pp. 437-444.

Erkan D, Sammaritano L, Lockshin MD. Management of the difficult aspects of antiphospholipid syndrome. In: Antiphospholipid Syndrome II. Autoimmune Thrombosis. Eds: Cervera R, Asherson RA, Piette J-C, Shoenfeld Y. Elsevier:Amsterdam, 2002, pp. 395-407.

Committee to Review the CDC Anthrax Vaccine Safety and Efficacy Research Program (Brachman, P., Chair), An Assessment of the CDC Anthrax Vaccine Safety and Efficacy

Research Program, Institute of Medicine Report, Washington:National Academy Press, 2002 (Committee member)

Lockshin MD. Systemic lupus erythematosus. In: Dale DC, Federman DD, eds. Scientific American Medicine. New York:WebMD Professional Publishing, 2003 Edition, pp. 1316-1329.

Erkan D, Lockshin MD. Antiphospholipid Syndrome. Bulletin on the Rheumatic Diseases 2003;52 (3): 1-4.

Bloom FE, Beal MF, Kupfer DJ, eds. The Dana Guide to Brain Health, New York:Dana Press, 2003 (contributor)

Lockshin MD. Pregnancy and Rheumatic Diseases. In: Koopman WJ, Boulware DW, Heudebert GR, eds. Clinical Primer of Rheumatology, Philadelphia:Lippincott Williams & Wilkens, 2003, pp. 236-242

Lockshin MD, Sammaritano LR. Lupus pregnancy. In: Lahita R, ed. Systemic Lupus Erythematosus. New York:Academic Press, 4th Edition, 2004, pp. 659-695

Erkan D, Roman M, Tenedios F, Lockshin MD. Cardiac Involvement in Antiphospholipid Syndrome. Handbook of Systemic Autoimmune Diseases, Doria A and Pauletto P (eds), Elsevier 2004, pp. 213-225.

Lockshin MD. Systemic lupus erythematosus. In: Dale DC, Federman DD, eds. ACP American Medicine. New York:WebMD Professional Publishing, 2004-2005 Edition, pp. 1362-1375.

Lockshin MD. Antiphospholipid syndrome, in Kelley’s Textbook of Rheumatology, Ruddy S, Harris ED, Jr., Sledge C, editors, Philadelphia:W B Saunders, 7th Edition, in press

Lockshin MD. Antiphospholipid syndrome, in Kelley’s Textbook of Rheumatology, Ruddy S, Harris ED, Jr., Sledge C, editors, Philadelphia:Elsevier Saunders, 2005 7th Edition, pp 1248-1257.

Tassiulas I, Lockshin MD. Systemic lupus erythematosus. In: Expert Guide to Rheumatology, Yee AMF and Paget SA, editors, Philadelphia:American College of Physicians, 2005, pp 71-94.

Erkan D, Lockshin MD. Antiphospholipid syndrome. In: Expert Guide to Rheumatology, Yee AMF and Paget SA, editors, Philadelphia:American College of Physicians, 2005, pp 71-94.

Lockshin M and Branch DW, eds, Handbook of Systemic Autoimmune Diseases, vol 4. Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases. Amsterdam:Elsevier 2006, 183 pp.

Lockshin M. Chapter 2. Sex Differences in Autoimmune Disease, pp 3-10.

Branch DW and Lockshin M. Chapter 6. Antiphospholipid Syndrome, pp 59-76.

Lockshin M. The future of Hughes Syndrome. In: Hughes Syndrome: Antiphospholipid Syndrome, Second Edition, Khamashta MA, editor, London:Springer-Verlag. 2006, pp. 579-582.

Erkan D, Lockshin MD. Antiphospholipid syndrome. Rich RR, Fleisher TA, Shearer WT, Schroeder HW Jr., Frew AJ, Weyand CM (eds). Clinical Immunology. Principles and Practice. 3rd edition. Chapter 61, pp 909-917. Philadelphia: Mosby-Elsevier, 2008

Lockshin MD, Derksen RHWM. New developments in lupus-associated antiphospholipid syndrome. Lupus 2008;17:443-446. Review.

Cutolo M, Matucci-Cerinic M, Lockshin MD, Ostensen M coeditors. Pregnancy in the rheumatic diseases. Rheumatology 2008; 47:Supplement 3.

Cutolo M, Matucci-Cerinic M, Lockshin M, Ostensen M. Introduction: new trends in pregnancy and rheumatic diseases. Pp iii-1, in Cutolo M, Matucci-Cerinic M, Lockshin MD, Ostensen M coeditors. Pregnancy in the rheumatic diseases. Rheumatology 2008; 47:Supplement 3. p 1

Doria A, Tincani A, Lockshin M. Challenges of lupus pregnancies. Pp iii 9-12, in Cutolo M, Matucci-Cerinic M, Lockshin MD, Ostensen M coeditors. Pregnancy in the rheumatic diseases. Rheumatology 2008; 47:Supplement 3, pp 9-12

Erkan D, Patel S, Nuzzo M, Gerosa M, Meroni PL, Tincani A, Lockshin MD. Management of the controversial aspects of the Antiphospholipid syndrome pregnancies: a guide for clinicians and researchers. Pp iii-19-22, in Cutolo M, Matucci-Cerinic M, Lockshin MD, Ostensen M coeditors. Pregnancy in the rheumatic diseases. Rheumatology 2008; 47:Supplement 3, pp 23-7

Ostensen M, Lockshin M, Doria A, Valesini G, Meroni P, Gordon C. Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs. Pp iii 28-31, in Cutolo M, Matucci-Cerinic M, Lockshin MD, Ostensen M coeditors. Pregnancy in the rheumatic diseases. Rheumatology 2008; 47:Supplement 3, pp 28-31

Lisa Mandl, MD, MPH

Selected Journal Articles:

Mandl LA, Folkerth RD, Pick MA, Weinblatt ME, Gravallese EM. Amyloid Myopathy Masquerading as Polymyositis. J.Rheum 2000;27:949-52.

Mandl LA Liang MH "Images of Lupus: Diving for Pearls." Lupus. 2000; 9: 565.

Mandl LA, Smith EL, Lew RA, Solomon DH, Shmerling RH. Using Antineutrophil Cytoplasmic Antibody Testing to Diagnose Vasculitis: Can Test-Ordering Guidelines Improve Diagnostic Accuracy? Arch Intern Med 2002;62:1509-1514.

Costenbader KH, Karlson EW, Liang MH, Mandl LA. Defining Lupus Cases for Clinical Studies: The Boston Weighted Criteria for the Classification of Systemic Lupus Erythematosus. J Rheumatol 2002;29:2545-50.

Mandl LA, Galvin DH, Bosch JP, George CC, Simmons BP, Axt TS, Fossel AH, Katz JN. Metacarpophalangeal Arthroplasty in Rheumatoid Arthritis: What Determines Satisfaction with Surgery? J Rheumatol 2002;29:2488-91.

Liang MH, Mandl LA, Costenbader KH, Fox F, Karlson EW. Atherosclerotic Vascular Disease in Systemic Lupus Erythematosus. J Nat Med Ass 2002;94:813-9.

Karlson EW, Mandl LA, Sangha O, Liang MH, Grodstein F. Risk Factors for Severe Hip Osteoarthritis in a Large Female Cohort Study. Am J Med 2003;114:93-8.

Solomon DH, Karlson EW, Rimm EB, Cannuscio CC, Mandl LA, Manson JE, Stampfer MJ, Curhan GC .Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 2003;107:1303-7.

Karlson EW, Mandl LA, Aweh GN, Grodstein F. Coffee Consumption and Risk of Rheumatoid Arthritis. Arthritis and Rheum 2003; 48: 3055-3060.

Karlson EW Mandl LA Grodstein F. Susan E. Hankinson, ScD. Do Breast Feeding and Other Reproductive Factors Influence Future Risk of Rheumatoid Arthritis. Arthritis and Rheum 2004; 50: 3458-3467.

Creel AH Losina E Mandl LA Marx RJ Mahomed NN Martin SD Martin TL Millet PJ Fossel AH Katz, JN. An Assessment of Willingness To Participate in a Randomized Trial of Arthroscopic Knee Surgery in Patients with Osteoarthritis. Contemporary Clinical Trials 2005; 26(2): 169-178.

Mandl LA Hotchkiss RB Adler RA Ariola LA Katz JN. Can the Carpometacarpal Joint Be Injected Accurately in the Office Setting? Implications for Therapy. Journal of Rheumatology 2006; 33: 1137-1139.

Lyman S Sherman S Carter TI Bach PB Mandl LA, Marx RG. Prevalence and risk factors for symptomatic thromboembolic events after shoulder arthroplasty. Clinical Orthopaedics and Related Research 2006; 448: 152-6.

Costenbader KH Feskanich D Mandl LA Karlson EW. Smoking Intensity, Duration and Cessation, and the Risk of Rheumatoid Arthritis in Women. Am J. Med. 2006; 119:503-511.

Mackenzie CR Mandl LA Reyes C Lachs M Magid S. Are Ambulatory Surgical Patients as Healthy as We Think? Using a Self-Reported Health Status Questionnaire to Identify Unsuspected Medical Comorbidities. Hospital for Special Surgery Journal. 2006; 2:121-126.

Benito-Garcia E Feskanich D Hu FB Mandl LA Karlson EW. Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study. Arthritis Research & Therapy. 2007; 9:R16.

Pearle AD Scanzello CR George S Mandl LA DiCarlo EF Peterson M Sculco TP Crow MK. Elevated High Sensitivity C-reactive Protein Levels are Associated With Local Inflammatory Findings in Patients With Osteoarthritis. Osteoarthritis and Cartilage 2006; 15:516-523.

Mandl LA Burke FD Wilgis EFS Lyman S Katz JN Chung KC. Could Pre-Operative Preferences and Expectations Influence Surgical Decision Making? Rheumatoid Arthritis Patients Contemplating Metacarpophalangeal Joint Arthroplasty. Plastic and Reconstructive Surgery. 2008; 121: 175-180.

Alpert D, Mandl LA, Erkan D, Yin W Peerschke, EI Salmon JE. Anti-heparin platelet factor 4 antibodies in systemic lupus erythematosus are associated with IgM antiphospholipid antibodies and the antiphospholipid syndrome. Ann Rheum Dis.2008; 6:395-401

Selected Book Chapters

Mandl LA Liang MH. "Is Rheumatoid Arthritis Decreasing in Incidence and Severity? A Critical Appraisal." In: Challenges in Rheumatoid Arthritis, Eds. Bird HA, Snaith ML, Blackwell Science Ltd, Oxford England; 1999: 281-299.

Mandl LA Esdaile J "Adult Still’s Disease." Up-to-Date. Ed. Rose B. Wellesley MA 1999.

Mandl LA Fortin PR Liang MH Branch WT. "Elbow, Hand, Knee, Hip and Foot Pain." In: Office Practice of Medicine, 4th Edition, Ed. Branch WT, Elsevier Science (USA), Philadelphia USA; 2003: 819-840

Mandl LA Liang MH. "Monitoring Patients with SLE." In: Systemic Lupus Erythematosus, 4th Edition, Ed. Lahita RG. Elsevier Science (USA) Philadelphia,USA; 2004: 619-631.

Harrison MJ Mandl LA. “Measuring Clinical Outcomes in Rheumatic Disease.” In: Manual of Rheumatology Outpatient Orthopedic Disorders, 5th Edition, Eds. Paget SA Gibofsky A Beary JF Sculco TP. Lippincott Williams and Wilkins, Philadelphia, USA; 2006:55-62.

Mandl LA. “The Epidemiology of Osteoarthritis” In: Osteoarthritis, 1st edition, Eds. Sharma L Berenbaum F. Elsevier Science, (USA) Philadelphia, USA; 2007: 1-15.